Inter-individual variability in drug response, be it efficacy or safety, is common and likely to
become an increasing problem globally given the growing elderly population requiring …

Globally, the number of people with multiple co-occurring diseases will increase
substantially over the coming decades, with important consequences for patients, carers …

The metabolome offers a dynamic, comprehensive, and precise picture of the phenotype.
Current high-throughput technologies have allowed the discovery of relevant metabolites …

Objective To examine the effect of optimising drug treatment on drug related hospital
admissions in older adults with multimorbidity and polypharmacy admitted to hospital …

Abstract Motivation Drug–drug interactions (DDIs) are one of the major concerns in
pharmaceutical research. Many machine learning based methods have been proposed for …

Due to the recent progress in Deep Neural Networks, Reinforcement Learning (RL) has
become one of the most important and useful technology. It is a learning method where a …

Objectives To provide national estimates of the number and clinical and economic burden of
medication errors in the National Health Service (NHS) in England. Methods We used UK …

Cytochrome P450 2D6 (CYP2D6) is a critical pharmacogene involved in the metabolism of~
20% of commonly used drugs across a broad spectrum of medical disciplines including …

Objective To compare the efficacy, safety, and cost effectiveness of direct acting oral
anticoagulants (DOACs) for patients with atrial fibrillation. Design Systematic review …

Background The pharmaceutical industry is in the midst of a productivity crisis and rates of
translation from bench to bedside are dismal. Patients are being let down by the current …