Members of the Prdm family are characterized by an N-terminal PR domain that is related to
the SET methyltransferase domain, and multiple zinc fingers that mediate sequence-specific …

The development of potent, specific, and pharmacologically viable chemical probes and
therapeutics is a central focus of chemical biology and therapeutic development. However, a …

Abstract γδ T cells are potent anticancer effectors with the potential to target tumours
broadly, independent of patient-specific neoantigens or human leukocyte antigen …

Epigenetic and epitranscriptomic networks have important functions in maintaining the
pluripotency of embryonic stem cells (ESCs) and somatic cell reprogramming. However, the …

A complex and highly orchestrated gene expression program chiefly establishes the
properties that define the adipocyte phenotype, in which the vast majority of factors are …

C-terminal binding protein family members function predominantly as transcriptional
corepressors in association with sequence specific DNA-binding transcriptional repressors …

ZNF750 controls epithelial homeostasis by inhibiting progenitor genes while inducing
differentiation genes, a role underscored by pathogenic ZNF750 mutations in cancer and …

The Krüppel-like zinc finger protein ZNF217 is a candidate oncogene in breast cancer. In
this study, we showed that high levels of expression of ZNF217 mRNA are associated with …

C-terminal binding protein (CtBP) family proteins CtBP1 and CtBP2 are highly homologous
transcriptional corepressors and are recruited by a large number of transcription factors to …

Clinical studies have revealed that breast cancers contain regions of intratumoral hypoxia
(reduced oxygen availability), which activates hypoxia-inducible factors (HIFs). The …