Abstract The application of Chiral Technology, or the (extensive) use of techniques or tools
for the determination of absolute stereochemistry and the enantiomeric or chiral separation …

Toxins produced by phytopathogenic fungi assume great importance because of their
involvement in several plant diseases. Although such pathogens are known to have …

In this paper, both Hartree− Fock (HF) and density functional theory (DFT) methods have
been used to make ab initio calculations of the optical rotatory power of selected molecules …

A straightforward synthesis of orthogonally protected PNA monomers is described. Protected
aminoethylglycine (Aeg) monomers were efficiently prepared by reductive amination of N …

Ab initio calculations of the optical rotatory power of the natural cytokine modulator
cytoxazone 1 and its trans-diastereomer 2, as well as the structural isomers cis-3 and trans-4 …

A solvent-free reaction employing a simple low-energy ball mill apparatus converts the
amino groups of adenosine, 2-deoxyadenosine, cytidine, 2-deoxycytidine, guanosine, and 2 …

The non-empirical assignment of the absolute configuration of (−)-naringenin, the aglycone
of (−)-naringin, a flavanone glycoside abundant in the albedo of immature grapefruits and …

The central nervous system glutamate receptors are an important target for drug discovery.
Herein we report initial investigations into the synthesis and glutamate receptor activity of 1 …

The nonempirical assignment of the absolute configuration of (+)-diplopyrone, the main
phytotoxin of Diplodia mutila, ie, an endophytic fungus, widespread in Sardinian oak forests …

During the optimization process that leads to drug candidates, bioisosterism is often used to
achieve improved potency/selectivity, optimal ADME-T profiles as well as reach intellectual …