T-cell factor/lymphoid enhancer factor (TCF/LEF) transcription factors are the major end
point mediators of Wnt/Wingless signaling throughout metazoans. TCF/LEFs are …

The Wnt signalling pathway is an ancient system that has been highly conserved during
evolution. It has a crucial role in the embryonic development of all animal species, in the …

THE cytoplasmic proteins β-catenin of vertebrates and armadillo of Drosophila have two
functions: they link the cadherin cell-adhesion molecules to the cytoskeleton1–4, and they …

XTcf-3 is a maternally expressed Xenopus homolog of the mammalian HMG box factors Tcf-
1 and Lef-1. The N-terminus of XTcf-3 binds to β-catenin. Microinjection of XTcf-3 mRNA in …

Wnt genes and components of Wnt signalling pathways have been implicated in a wide
spectrum of important biological phenomena, ranging from early organismal development to …

The epithelial–mesenchymal transition is essential in both embryonic development and the
progression of carcinomas. Wnt signaling and cadherin-mediated adhesion have been …

The HIV-1 Tat protein regulates transcription elongation through binding to the viral TAR
RNA stem-loop structure. We have isolated a novel 87 kDa cyclin C–related protein (cyclin …

Lymphoid enhancer factor 1 (LEF-1) is a sequence-specific DNA-binding protein that is
expressed in pre-B and T lymphocytes of adult mice, and in the neural crest …

The HMG-1 and-2 proteins have three structural domains. Two of these domains, termed A
and B, have significant homology with each other, and the third comprises an acidic carboxy …

LEF-1/TCF transcription factors mediate a nuclear response to Wnt signals by interacting
with β-catenin. Wnt signaling and other cellular events that increase the stability of β-catenin …