The purpose of this review is to summarize essential pharmacological, pharmaceutical, and
clinical aspects in the field of orally inhaled therapies that may help scientists seeking to …

Fungi and bacteria encounter each other in various niches of the human body. There, they
interact directly with one another or indirectly via the host response. In both cases …

Background Hypertonic saline enhances mucociliary clearance and may lessen the
destructive inflammatory process in the airways. This is an update of a previously published …

Pseudomonas aeruginosa is the major pathogen in the cystic fibrosis (CF) lung. Prevalence
is high and, once acquired, chronic infection will almost always ensue. Several hypotheses …

Rationale Bronchiectasis is characterised by excessive production of mucus and pulmonary
exacerbations. Inhaled osmotic agents may enhance mucociliary clearance, but few long …

There is controversy over whether abnormalities in the salt concentration or volume of
airway surface liquid (ASL) initiate cystic fibrosis (CF) airway disease. In vivo studies of CF …

Objective: To determine the utility of inhaled hypertonic saline solution to treat infants
hospitalized with viral bronchiolitis. Design: Randomized, double-blind, controlled trial. Fifty …

Background: Cough-suppressant therapy, previously termed nonspecific antitussive therapy,
incorporates the use of pharmacologic agents with mucolytic effects and/or inhibitory effects …

Objective To determine the utility of inhaled hypertonic saline solution to treat ambulatory
infants with viral bronchiolitis. Design Randomized, double-blind, controlled trial. Sixty-five …