Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that
regulates various biological processes, including proliferation, metastasis, angiogenesis …

Targeting pathogenic proteins with small-molecule inhibitors (SMIs) has become a widely
used strategy for treating malignant tumors. However, most intracellular proteins have been …

Natural compounds are rich in pharmacological properties that are a hot topic in
pharmaceutical research. The quinoline ring plays important roles in many biological …

Targeted protein degradation (TPD), a promising therapeutic strategy in drug discovery, has
great potential to regulate the endogenous degradation of undruggable targets with small …

Gastric cancer remains a significant health burden worldwide. In continuation of our
previous study and development of effective small molecules against gastric cancer, a series …

The emergence of multidrug resistance (MDR) in malignant tumors is one of the major
threats encountered currently by many chemotherapeutic agents. Among the various …

The emergence of multidrug resistance (MDR) in malignant tumors is one of the leading
threats encountered currently by many chemotherapeutic agents. A proposed strategy to …

Targeted protein degradation (TPD) is a rapidly growing field in modern drug discovery that
aims to regulate the intracellular levels of proteins by harnessing the cell's innate …

We previously discovered extrahepatic cytochrome P450 1B1 (CYP1B1) degraders able to
overcome drug resistance toward docetaxel using a PROTACs technology, however, the …

Human cytochrome P450 1B1 (CYP1B1) is an extrahepatic heme-containing
monooxygenase. CYP1B1 contributes to the oxidative metabolism of xenobiotics, drugs, and …