A comprehensive review on β-lapachone: Mechanisms, structural modifications, and therapeutic potentials
Q Gong, J Hu, P Wang, X Li, X Zhang - European Journal of Medicinal …, 2021 - Elsevier
Abstract β-Lapachone (β-lap, 1), an ortho-naphthoquinone natural product isolated from the
lapacho tree (Tabebuia avellanedae) in many regions of South America, has received …
lapacho tree (Tabebuia avellanedae) in many regions of South America, has received …
Lawsone in organic synthesis
Lawsone (1) is a special naphthoquinone that is useful for many applications in various
scientific and technological fields. For over 100 years, it has been used as the starting …
scientific and technological fields. For over 100 years, it has been used as the starting …
Structure-Based Identification of Naphthoquinones and Derivatives as Novel Inhibitors of Main Protease Mpro and Papain-like Protease PLpro of SARS-CoV-2
The worldwide COVID-19 pandemic caused by the coronavirus SARS-CoV-2 urgently
demands novel direct antiviral treatments. The main protease (Mpro) and papain-like …
demands novel direct antiviral treatments. The main protease (Mpro) and papain-like …
Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor
Using machine learning, targets were identified for β-lapachone. Resorting to biochemical
assays, β-lapachone was validated as a potent, ligand efficient, allosteric and reversible …
assays, β-lapachone was validated as a potent, ligand efficient, allosteric and reversible …
Electrochemical parameters and techniques in drug development, with an emphasis on quinones and related compounds
EA Hillard, FC de Abreu, DCM Ferreira… - Chemical …, 2008 - pubs.rsc.org
This review article summarizes recent applications of electrochemical techniques to redox-
active drug development and mechanistic studies. It includes a general introduction to the …
active drug development and mechanistic studies. It includes a general introduction to the …
Synthesis and antitumor activity of selenium-containing quinone-based triazoles possessing two redox centres, and their mechanistic insights
Abstract Selenium-containing quinone-based 1, 2, 3-triazoles were synthesized using click
chemistry, the copper catalyzed azide-alkyne 1, 3-dipolar cycloaddition, and evaluated …
chemistry, the copper catalyzed azide-alkyne 1, 3-dipolar cycloaddition, and evaluated …
Potent naphthoquinones against antimony-sensitive and-resistant Leishmania parasites: Synthesis of novel α-and nor-α-lapachone-based 1, 2, 3-triazoles by copper …
TT Guimarães, FR Maria do Carmo, JS Lanza… - European Journal of …, 2013 - Elsevier
Continuing our screening program for novel anti-parasite compounds, we synthesized
seven 1, 4-naphthoquinones coupled to 1, 2, 3-triazoles, five nor-β-lapachone-based 1, 2, 3 …
seven 1, 4-naphthoquinones coupled to 1, 2, 3-triazoles, five nor-β-lapachone-based 1, 2, 3 …
Syntheses of chromenes and chromanes via o‐quinone methide intermediates
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Weakly-coordinating N-oxide and carbonyl groups for metal-catalyzed C–H activation: the case of A-ring functionalization
Compounds featuring weakly-coordinating N-oxides or carbonyl groups, as for instance,
quinoline N-oxide and quinonoid systems represent important structural scaffolds with …
quinoline N-oxide and quinonoid systems represent important structural scaffolds with …
[HTML][HTML] 1, 2, 3-Triazole-, arylamino-and thio-substituted 1, 4-naphthoquinones: Potent antitumor activity, electrochemical aspects, and bioisosteric replacement of C …
Triazole-, arylamino-and thio-substituted naphthoquinones (24, 8, and 2 representatives,
respectively) were synthesized in moderate yields and evaluated against several human …
respectively) were synthesized in moderate yields and evaluated against several human …