Recent advances in the stereoselective synthesis of β-amino acids

M Liu, MP Sibi - Tetrahedron, 2002 - Elsevier
1.6. 1. Diastereoselective conjugate addition of chiral nucleophiles 8011 1.6. 2.
Diastereoselective conjugate addition of an achiral amine to a chiral trap 8012 1.6. 3 …

Preparation of achiral and of enantiopure geminally disubstituted β‐amino acids for β‐peptide synthesis

S Abele, D Seebach - European Journal of Organic Chemistry, 2000 - Wiley Online Library
While geminally disubstituted α‐amino acids are helix‐inducing residues in α‐peptides, gem‐
disubstituted β‐amino acids are predicted not to fit into any of the three major secondary …

Preparation and Structure of β‐Peptides Consisting of Geminally Disubstituted β2,2‐ and β3,3‐Amino Acids: A Turn Motif for β‐Peptides

D Seebach, S Abele, T Sifferlen, M Hänggi… - Helvetica chimica …, 1998 - Wiley Online Library
We report on the synthesis of new and previously described β‐peptides (1–6), consisting of
up to twelve β2, 2‐or β3, 3‐geminally disubstituted β‐amino acids which do not fit into any of …

Enantioseparation of β2-amino acids on cinchona alkaloid-based zwitterionic chiral stationary phases. Structural and temperature effects

I Ilisz, N Grecsó, A Aranyi, P Suchotin… - … of Chromatography A, 2014 - Elsevier
The enantiomers of sixteen unusual β 2-amino acids were directly separated on chiral
stationary phases containing quinine-or quinidine-based zwitterionic selectors. The effects …

[HTML][HTML] Comparison of the separation performances of cinchona alkaloid-based zwitterionic stationary phases in the enantioseparation of β2-and β3-amino acids

I Ilisz, N Grecsó, A Misicka, D Tymecka, L Lázár… - Molecules, 2015 - mdpi.com
The enantiomers of twelve unusual β 2-and β 3-homoamino acids containing the same side-
chains were separated on chiral stationary phases containing a quinine-or quinidine-based …

Synthesis of novel C2-symmetric chiral bis (oxazoline) ligands and their application in the enantioselective addition of diethylzinc to aldehydes

B Fu, DM Du, J Wang - Tetrahedron: Asymmetry, 2004 - Elsevier
Novel chiral bis (oxazoline) ligands bearing dibenzo [a, c] cycloheptadiene and a dihydroxy
group have been synthesized and their application in the catalytic asymmetric addition of …

Enantioselective synthesis of β-amino acids. Part 9: Preparation of enantiopure α, α-disubstituted β-amino acids from 1-benzoyl-2 (S)-tert-butyl-3 …

E Juaristi, M Balderas, Y Ramı́rez-Quirós - Tetrahedron: Asymmetry, 1998 - Elsevier
Double alkylation of enantiopure N, N-acetal pyrimidinone (S)-1, a masked chiral derivative
of β-alanine prepared from (S)-asparagine, proceeds with high stereoselectivity to give C (5) …

Novel chiral dibenzo [a, c] cycloheptadiene bis (oxazoline) and catalytic enantioselective cyclopropanation of styrene

DM Du, B Fu, WT Hua - Tetrahedron, 2003 - Elsevier
A series of chiral C2-symmetric bis (oxazoline) ligands containing dibenzo [a, c]
cycloheptadiene units were synthesized. The copper complexes, prepared in situ from …

The Structural Characterization of Folded Peptides Containing the Conformationally Constrained β‐Amino Acid Residue β2,2Ac6c

K Basuroy, V Karuppiah, N Shamala… - Helvetica Chimica …, 2012 - Wiley Online Library
Backbone alkylation has been shown to result in a dramatic reduction in the conformational
space that is sterically accessible to α‐amino acid residues in peptides. By extension, the …

Efficient Synthesis of Symmetrical α, α-Disubstituted β-Amino Acids and α, α-Disubstituted Aldehydes via Dialkylation of Nucleophilic β-Alanine Equivalent

D Lin, G Deng, J Wang, X Ding, H Jiang… - The Journal of Organic …, 2010 - ACS Publications
Homologation of the nucleophilic β-alanine equivalent β-Ala Ni (II)-PABP [Ni (II) complex of
β-alanine Schiff base with 2-[N-(α-picolyl) amino] benzophenone (PABP), 1] via alkyl halide …