Pyrrole-containing hybrids as potential anticancer agents: An insight into current developments and structure-activity relationships

L Long, H Zhang, ZH Zhou, L Duan, D Fan… - European Journal of …, 2024 - Elsevier
Cancer poses a significant threat to human health. Therefore, it is urgent to develop potent
anti-cancer drugs with excellent inhibitory activity and no toxic side effects. Pyrrole and its …

Multiple molecular targets mediated antioxidant activity, molecular docking, ADMET, QSAR and bioactivity studies of halo substituted urea derivatives of α-Methyl-l …

N Vadabingi, VKR Avula, GV Zyryanov, S Vallela… - Bioorganic …, 2020 - Elsevier
A series of novel α-methyl-l-DOPA urea derivatives viz., 3-(3, 4-dihydroxyphenyl)-2-methyl-2-
(3-halo/trifluoromethyl substituted phenyl ureido) propanoic acids (6a-e) have been …

Purification and characterization of avocado (Persea americana) polyphenol oxidase by affinity chromatography

M Moeini Alishah, S Yıldız, Ç Bilen… - Preparative …, 2023 - Taylor & Francis
Polyphenol oxidase (PPO) enzyme was purified from avocado (Persea americana) by
ammonium sulfate precipitation 0-80%, dialysis and affinity chromatography …

Synthesis, antioxidant activity and bioinformatics studies of L-3-hydroxytyrosine templated N-alkyl/aryl substituted urea/thioureas

U Kollu, VKR Avula, S Vallela, VR Pasupuleti… - Bioorganic …, 2021 - Elsevier
A new series of urea/thiourea derivatives have been efficiently synthesized from the reaction
of L-3-hydroxytyrosine with selective isocyanates/isothiocyanates and characterized by Infra …

Purification of damson plum polyphenol oxidase by affinity chromatography and investigation of metal effects on enzyme activity

S Yıldız, Ç Bilen, E Karakuş - Preparative Biochemistry & …, 2022 - Taylor & Francis
Polyphenol oxidase (PPO) was firstly purified from damson plum as a high antioxidant
source. PPO was treated by 0–80% ammonium sulfate precipitation and dialysis …

[HTML][HTML] Purification and Characterization of Polyphenol Oxidase in the Fruits of Opuntia ficus-indica

D Demir, S Kabak, K Çağlayan - Biology, 2023 - mdpi.com
Simple Summary Opuntia ficus-indica (L.) Mill.(OFI) is a member of the Cactaceae family. Its
fruits are available in a wide range of colors, including orange, lime green, purple, and red …

Hunig's base catalyzed synthesis of new 1-(2, 3-dihydro-1H-inden-1-yl)-3-aryl urea/thiourea derivatives as potent antioxidants and 2HCK enzyme growth inhibitors

VL Reddy, VKR Avula, GV Zyryanov, S Vallela… - Bioorganic …, 2020 - Elsevier
Abstract A series of 1-(2, 3-dihydro-1H-indan-1-yl)-3-aryl urea/thiourea derivatives (4a-j)
have been synthesized from the reaction of 2, 3-dihydro-1H-inden-1-amine (2) with various …

Synthesis and Investigation of Carbonic Anhydrase I and II Activity of Dihydrobenzo[h]Quinazolin-2-yl Thiourea Compounds

M Taşcı, M Arslan, K Çıkrıkcı, A Ergun, N Gençer… - Pharmaceutical …, 2023 - Springer
Thirteen novel compounds in a series of dihydrobenzo [h] quinazolin-2-yl thiourea
compounds (7a–m) were synthesized and characterized using FT-IR, 1H, 13C NMR …

Synthesis and biological assessment of carbazole linked pyrazole schiff bases and diarylthiourea derivatives

GD Shirole, GR Pandhare, AG Gadhave… - Croatica Chemica …, 2020 - hrcak.srce.hr
Sažetak In this study,(E)-9-ethyl-N-((1, 3-diphenyl-1H-pyrazol-4-ylmethylene)-9H-carbazol-3-
amine (3a–f) and 1-(9-ethyl-9H-carbazol-6-yl)-3-phenylthiourea (5a–f) derivatives were …

[PDF][PDF] Three-Dimensional Fingerprint Spectroscopy Study on the Biopolymer System of Polyphenol Oxidase Binding with Cumalic Acid

CY Wu, WQ Ling, YC Yao, M Guo, N Nuraje - 2022 - researchgate.net
The protection of Cumalic acid (CA), antioxidant, in the biochemical process in nature has
aroused great interest. Polyphenol oxidase (PPO), an enzyme, plays a vital function in aging …