Adipose-tissue plasticity in health and disease
Adipose tissue, colloquially known as" fat," is an extraordinarily flexible and heterogeneous
organ. While historically viewed as a passive site for energy storage, we now appreciate that …
organ. While historically viewed as a passive site for energy storage, we now appreciate that …
The role of hepatokines in NAFLD
Non-alcoholic fatty liver disease (NAFLD) is not only a consequence of insulin resistance,
but it is also an important cause of insulin resistance and major non-communicable diseases …
but it is also an important cause of insulin resistance and major non-communicable diseases …
Mechanisms and disease consequences of nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide. Its
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …
The aetiology and molecular landscape of insulin resistance
Insulin resistance, defined as a defect in insulin-mediated control of glucose metabolism in
tissues—prominently in muscle, fat and liver—is one of the earliest manifestations of a …
tissues—prominently in muscle, fat and liver—is one of the earliest manifestations of a …
Metabolic (dysfunction)-associated fatty liver disease in individuals of normal weight
Metabolic (dysfunction)-associated fatty liver disease (MAFLD) affects up to a third of the
global population; its burden has grown in parallel with rising rates of type 2 diabetes …
global population; its burden has grown in parallel with rising rates of type 2 diabetes …
[HTML][HTML] The energy balance model of obesity: beyond calories in, calories out
ABSTRACT A recent Perspective article described the “carbohydrate-insulin model (CIM)” of
obesity, asserting that it “better reflects knowledge on the biology of weight control” as …
obesity, asserting that it “better reflects knowledge on the biology of weight control” as …
Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics
In mammals, the white adipocyte is a cell type that is specialized for storage of energy (in the
form of triacylglycerols) and for energy mobilization (as fatty acids). White adipocyte …
form of triacylglycerols) and for energy mobilization (as fatty acids). White adipocyte …
The integrative biology of type 2 diabetes
M Roden, GI Shulman - Nature, 2019 - nature.com
Obesity and type 2 diabetes are the most frequent metabolic disorders, but their causes
remain largely unclear. Insulin resistance, the common underlying abnormality, results from …
remain largely unclear. Insulin resistance, the common underlying abnormality, results from …
Effects of cotadutide on metabolic and hepatic parameters in adults with overweight or obesity and type 2 diabetes: a 54-week randomized phase 2b study
R Nahra, T Wang, KM Gadde, J Oscarsson… - Diabetes …, 2021 - Am Diabetes Assoc
OBJECTIVE Cotadutide, a dual GLP-1 and glucagon receptor agonist, is under development
for nonalcoholic steatohepatitis (NASH) and chronic kidney disease with type 2 diabetes …
for nonalcoholic steatohepatitis (NASH) and chronic kidney disease with type 2 diabetes …
Obesity as a multisystem disease: Trends in obesity rates and obesity‐related complications
Obesity is a chronic multisystem disease associated with increased morbidity and mortality.
The increasing prevalence of obesity makes it a major healthcare challenge across both …
The increasing prevalence of obesity makes it a major healthcare challenge across both …