The Mutagenic Plasticity of the Cholera Toxin B-Subunit Surface Residues: Stability and Affinity

CW Au, I Manfield, ME Webb, E Paci, WB Turnbull… - Toxins, 2024 - mdpi.com
Mastering selective molecule trafficking across human cell membranes poses a formidable
challenge in healthcare biotechnology while offering the prospect of breakthroughs in drug …

Piggybacking on the cholera toxin: Identification of a CTB-binding protein as an approach for targeted delivery of proteins to motor neurons

MR Balmforth, J Haigh, V Kumar, W Dai… - Bioconjugate …, 2021 - ACS Publications
A significant unmet need exists for the delivery of biologic drugs such as polypeptides or
nucleic acids to the central nervous system for the treatment and understanding of …

Synthesis of cholera toxin B subunit glycoconjugates using site-specific orthogonal oxime and sortase ligation reactions

JP Dolan, DC Machin, S Dedola, RA Field… - Frontiers in …, 2022 - frontiersin.org
The chemoenzymatic synthesis of a series of dual N-and C-terminal–functionalized cholera
toxin B subunit (CTB) glycoconjugates is described. Mucin 1 peptides bearing different …