[HTML][HTML] Tumor suppressor p53: Biology, signaling pathways, and therapeutic targeting
LJH Borrero, WS El-Deiry - Biochimica et Biophysica Acta (BBA)-Reviews …, 2021 - Elsevier
TP53 is the most commonly mutated gene in human cancer with over 100,000 literature
citations in PubMed. This is a heavily studied pathway in cancer biology and oncology with a …
citations in PubMed. This is a heavily studied pathway in cancer biology and oncology with a …
Gain-of-function mutant p53 in cancer progression and therapy
Abstract p53 is a key tumor suppressor, and loss of p53 function is frequently a prerequisite
for cancer development. The p53 gene is the most frequently mutated gene in human …
for cancer development. The p53 gene is the most frequently mutated gene in human …
MicroRNA in lung cancer: role, mechanisms, pathways and therapeutic relevance
Lung cancer is the cardinal cause of cancer-related deaths with restricted recourse of
therapy throughout the world. Clinical success of therapies is not very promising due to-late …
therapy throughout the world. Clinical success of therapies is not very promising due to-late …
Mutant p53 gain-of-function: role in cancer development, progression, and therapeutic approaches
E Alvarado-Ortiz, KG de la Cruz-López… - Frontiers in cell and …, 2021 - frontiersin.org
Frequent p53 mutations (mutp53) not only abolish tumor suppressor capacities but confer
various gain-of-function (GOF) activities that impacts molecules and pathways now regarded …
various gain-of-function (GOF) activities that impacts molecules and pathways now regarded …
Mutant p53 in cancer therapy—the barrier or the path
Since wild-type p53 is central for maintaining genomic stability and preventing oncogenesis,
its coding gene TP53 is highly mutated in~ 50% of human cancers, and its activity is almost …
its coding gene TP53 is highly mutated in~ 50% of human cancers, and its activity is almost …
Gain-of-function mutant p53: all the roads lead to tumorigenesis
Y Stein, V Rotter, R Aloni-Grinstein - International journal of molecular …, 2019 - mdpi.com
The p53 protein is mutated in about 50% of human cancers. Aside from losing the tumor-
suppressive functions of the wild-type form, mutant p53 proteins often acquire inherent …
suppressive functions of the wild-type form, mutant p53 proteins often acquire inherent …
Circulating microRNAs: new biomarkers in diagnosis, prognosis and treatment of cancer
A Allegra, A Alonci, S Campo… - International …, 2012 - spandidos-publications.com
MicroRNAs (miRNAs) are small non-coding, endogenous, single-stranded RNAs. MiRNAs
have been implicated in different areas such as the immune response, neural development …
have been implicated in different areas such as the immune response, neural development …
Recent trends in targeting miRNAs for cancer therapy
Objectives MicroRNAs (miRNAs) are a type of small noncoding RNA employed by the cells
for gene regulation. A single miRNA, typically 22 nucleotides in length, can regulate the …
for gene regulation. A single miRNA, typically 22 nucleotides in length, can regulate the …
The rebel angel: mutant p53 as the driving oncogene in breast cancer
Breast cancer is the most frequent invasive tumor diagnosed in women, causing over 400
000 deaths yearly worldwide. Like other tumors, it is a disease with a complex …
000 deaths yearly worldwide. Like other tumors, it is a disease with a complex …
Exposure to a mixture of heavy metals induces cognitive impairment: genes and microRNAs involved
Converging evidence demonstrates that microRNAs (miRNAs) play an important role in the
etiology of cognitive impairment. Thus, we aim to:(i) identify the molecular mechanisms of …
etiology of cognitive impairment. Thus, we aim to:(i) identify the molecular mechanisms of …