Hirschsprung disease (HSCR) is a rare congenital intestinal disease that occurs in 1 in
5,000 live births. HSCR is characterized by the absence of ganglion cells in the myenteric …

Background Hirschsprung's disease (HSCR) is a serious congenital bowel disorder with a
prevalence of 1/5000. Currently, there is a lack of systematically developed guidelines to …

The neural crest (NC) is a transient, multipotent and migratory cell population that generates
an astonishingly diverse array of cell types during vertebrate development. These cells …

Diagnosis or exclusion of Hirschsprung disease (HSCR) is a frequent exercise in any
pediatric hospital. Although HSCR may present at different ages and with varied clinical …

Hirschsprung's disease is a neurocristopathy, caused by defective migration, proliferation,
differentiation and survival of neural crest cells, leading to gut aganglionosis. It usually …

Purpose Numerous studies have investigated the prevalence of constipation and fecal
incontinence (FI) in the general population and, even though these disorders are known to …

The enteric nervous system (ENS) controls many aspects of intestinal homeostasis,
including parameters that shape the habitat of microbial residents. Previously we showed …

Objectives: The aim of the study was to characterize the microbiota profiles of patients with
Hirschsprung disease (HD) and to evaluate this in relation to postoperative bowel function …

Introduction Congenital anomalies are the fifth leading cause of death in children< 5 years of
age globally, contributing an estimated half a million deaths per year. Very limited literature …

Objective This study describes core outcomes of Hirschsprung's disease (HD) in a UK-wide
cohort of primary school-aged children. Design A prospective cohort study conducted from 1 …