Ischemic stroke is one of the leading causes of death and also a major cause of adult
disability worldwide. Revascularization via reperfusion therapy is currently a standard …

Due to the aging population in the world, neurodegenerative diseases have become a
serious public health issue that greatly impacts patients' quality of life and adds a huge …

Background/objectives Obesity is a risk factor in the development of type 2 diabetes mellitus
(DM2), which is associated with increased morbidity and mortality, predominantly as a result …

Hepatic ischemia and reperfusion (IR) injury is closely linked to oxidative mitochondrial
damage. Since mitochondrial quality control (QC) plays a pivotal role in the recovery of …

Abstract Linoleic acid (LA; 18: 2 n-6), the most abundant polyunsaturated fatty acid in the US
diet, is a precursor to oxidized metabolites that have unknown roles in the brain. Here, we …

To investigate the effect of 14, 15-EET on the parthanatos in neurons induced by cerebral
ischemia and reperfusion, middle cerebral artery occlusion and reperfusion (MCAO/R) and …

Eicosatrienoic acids (EETs) are a class of intermediates produced during arachidonic acid
metabolism mediated by cytochrome P450 epoxygenases that exert multiple physiological …

Obesity is a risk factor for vascular dysfunction and insulin resistance. The study aim was to
demonstrate that adipocyte-specific HO-1 (heme oxygenase-1) gene therapy is a …

Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid (AA) into biologically
active epoxyeicosatrienoic acids (EETs), forming a pivotal metabolic pathway (AA-CYP …

Background/Objectives. Obesity and metabolic syndrome and associated adiposity are a
systemic condition characterized by increased mitochondrial dysfunction, inflammation, and …