CAR-cell therapy in the era of solid tumor treatment: current challenges and emerging therapeutic advances
In the last decade, Chimeric Antigen Receptor (CAR)-T cell therapy has emerged as a
promising immunotherapeutic approach to fight cancers. This approach consists of …
promising immunotherapeutic approach to fight cancers. This approach consists of …
Roles of natural killer cells in immunity to cancer, and applications to immunotherapy
Great strides have been made in recent years towards understanding the roles of natural
killer (NK) cells in immunity to tumours and viruses. NK cells are cytotoxic innate lymphoid …
killer (NK) cells in immunity to tumours and viruses. NK cells are cytotoxic innate lymphoid …
CAR race to cancer immunotherapy: from CAR T, CAR NK to CAR macrophage therapy
Adoptive cell therapy with chimeric antigen receptor (CAR) immunotherapy has made
tremendous progress with five CAR T therapies approved by the US Food and Drug …
tremendous progress with five CAR T therapies approved by the US Food and Drug …
Tumor-infiltrating natural killer cells
B Cózar, M Greppi, S Carpentier, E Narni-Mancinelli… - Cancer discovery, 2021 - AACR
Because of their potent antitumor activity and their proinflammatory role, natural killer (NK)
cells are at the forefront of efforts to develop immuno-oncologic treatments. NK cells …
cells are at the forefront of efforts to develop immuno-oncologic treatments. NK cells …
Therapeutic implications of tumor microenvironment in lung cancer: focus on immune checkpoint blockade
C Genova, C Dellepiane, P Carrega… - Frontiers in …, 2022 - frontiersin.org
In the last decade, the treatment of non-small cell lung cancer (NSCLC) has been
revolutionized by the introduction of immune checkpoint inhibitors (ICI) directed against …
revolutionized by the introduction of immune checkpoint inhibitors (ICI) directed against …
Defining the role of natural killer cells in COVID-19
Natural killer (NK) cells are critical effectors of antiviral immunity. Researchers have
therefore sought to characterize the NK cell response to coronavirus disease 2019 (COVID …
therefore sought to characterize the NK cell response to coronavirus disease 2019 (COVID …
Managing the immune microenvironment of osteosarcoma: the outlook for osteosarcoma treatment
Osteosarcoma, with poor survival after metastasis, is considered the most common primary
bone cancer in adolescents. Notwithstanding the efforts of researchers, its five-year survival …
bone cancer in adolescents. Notwithstanding the efforts of researchers, its five-year survival …
The expanding role for small molecules in immuno-oncology
R Offringa, L Kötzner, B Huck, K Urbahns - Nature Reviews Drug …, 2022 - nature.com
The advent of immune checkpoint inhibition (ICI) using antibodies against PD1 and its
ligand PDL1 has prompted substantial efforts to develop complementary drugs. Although …
ligand PDL1 has prompted substantial efforts to develop complementary drugs. Although …
Natural killer cells: from innate to adaptive features
AM Mujal, RB Delconte, JC Sun - Annual review of immunology, 2021 - annualreviews.org
Natural killer (NK) cells are innate lymphocytes that provide critical host defense against
pathogens and cancer. Originally heralded for their early and rapid effector activity, NK cells …
pathogens and cancer. Originally heralded for their early and rapid effector activity, NK cells …
[HTML][HTML] NK cells and ILCs in tumor immunotherapy
Cells of the innate immunity play an important role in tumor immunotherapy. Thus, NK cells
can control tumor growth and metastatic spread. Thanks to their strong cytolytic activity …
can control tumor growth and metastatic spread. Thanks to their strong cytolytic activity …