Multimodal treatment strategies for patients with rectal cancer are increasingly including the
possibility of organ preservation, through nonoperative management or local excision …

Rectal cancer treatment has evolved during the past 40 years with the use of a standardized
surgical technique for tumour resection: total mesorectal excision. A dramatic reduction in …

Radiographic imaging is routinely used to evaluate treatment response in solid tumors.
Current imaging response metrics do not reliably predict the underlying biological response …

Background GRECCAR 2 was the first multicentre, randomised trial to compare local
excision with total mesorectal excision in downstaged low rectal cancer. Encouraging …

Background Radical surgery via total mesorectal excision might not be the optimal first-line
treatment for early-stage rectal cancer. An organ-preserving strategy with selective total …

Photodynamic therapy (PDT) has been developed as a potential cancer treatment approach
owing to its non-invasiveness, spatiotemporal control and limited side effects. Currently …

Importance Treatment of rectal cancer is shifting toward organ preservation aiming to reduce
surgery-related morbidity. Short-term outcomes of organ-preserving strategies are …

Aim Little is known about the pathophysiology of low anterior resection syndrome (LARS),
and evidence concerning the management of patients diagnosed with this condition is …

According to the main international clinical guidelines, the recommended treatment for
locally-advanced rectal cancer is neoadjuvant chemoradiotherapy followed by surgery …

Importance A watch-and-wait approach for patients with rectal cancer and a clinical
complete response after neoadjuvant chemoradiotherapy or radiotherapy is associated with …