Biology and significance of alpha‐fetoprotein in hepatocellular carcinoma

PR Galle, F Foerster, M Kudo, SL Chan… - Liver …, 2019 - Wiley Online Library
Hepatocellular carcinoma (HCC) is one of the most common causes of cancer‐related
deaths globally due, in part, to the majority of patients being diagnosed with intermediate or …

[HTML][HTML] Biomarkers in hepatocellular carcinoma: diagnosis, prognosis and treatment response assessment

F Piñero, M Dirchwolf, MG Pessôa - Cells, 2020 - mdpi.com
Hepatocellular carcinoma (HCC) is one of the main cancer-related causes of death
worldwide. Thus, there is a constant search for improvement in screening, diagnosis, and …

[PDF][PDF] Alpha-fetoprotein as a potential surrogate biomarker for atezolizumab+ bevacizumab treatment of hepatocellular carcinoma

AX Zhu, F Dayyani, CJ Yen, Z Ren, Y Bai… - Clinical Cancer …, 2022 - aacrjournals.org
Purpose: Atezolizumab+ bevacizumab is the new standard of care for systemic treatment-
naive, unresectable hepatocellular carcinoma (HCC). This exploratory study investigated on …

HCC and angiogenesis: possible targets and future directions

AX Zhu, DG Duda, DV Sahani, RK Jain - Nature reviews Clinical …, 2011 - nature.com
Hepatocellular carcinoma (HCC), the most common primary liver tumor, is notoriously
resistant to systemic therapies, and often recurs even after aggressive local therapies. HCCs …

Ten years of sorafenib in hepatocellular carcinoma: Are there any predictive and/or prognostic markers?

G Marisi, A Cucchetti, P Ulivi, M Canale… - World journal of …, 2018 - pmc.ncbi.nlm.nih.gov
Sorafenib has been considered the standard of care for patients with advanced
unresectable hepatocellular carcinoma (HCC) since 2007 and numerous studies have …

ACSL4 is a predictive biomarker of sorafenib sensitivity in hepatocellular carcinoma

J Feng, P Lu, G Zhu, SC Hooi, Y Wu, X Huang… - Acta Pharmacologica …, 2021 - nature.com
Sorafenib is the first-line treatment of advanced hepatocellular carcinoma (HCC). However,
there is a lack of validated biomarkers to predict sorafenib sensitivity. In this study we …

[PDF][PDF] Progress and challenges of predictive biomarkers for immune checkpoint blockade

Y Lei, X Li, Q Huang, X Zheng, M Liu - Frontiers in Oncology, 2021 - frontiersin.org
Over the past decade, immune checkpoint blockade (ICB) therapy has revolutionized the
outlook for oncology with significant and sustained improvement in the overall patient …

systemic treatment of hepatocellular carcinoma

M Pinter, M Peck‐Radosavljevic - Alimentary pharmacology & …, 2018 - Wiley Online Library
Background The approval of the tyrosine kinase inhibitor sorafenib in 2007 marked a
milestone in the treatment of hepatocellular carcinoma, as sorafenib was the first systemic …

Presence of EpCAM‐positive circulating tumor cells as biomarker for systemic disease strongly correlates to survival in patients with hepatocellular carcinoma

K Schulze, C Gasch, K Staufer… - … journal of cancer, 2013 - Wiley Online Library
Current imaging technologies do not sufficiently detect micrometastasis and therefore do not
allow adequate stratification of patients with hepatocellular carcinoma (HCC) for curative or …

Comparison of tumor response by Response Evaluation Criteria in Solid Tumors (RECIST) and modified RECIST in patients treated with sorafenib for hepatocellular …

J Edeline, E Boucher, Y Rolland, E Vauléon, M Pracht… - Cancer, 2012 - Wiley Online Library
BACKGROUND: A significant improvement in overall survival (OS) was demonstrated in
patients with advanced hepatocellular carcinoma (HCC) who received sorafenib (Sor) in the …