Polymyxin B versus colistin: an update
Y Cai, W Lee, AL Kwa - Expert review of anti-infective therapy, 2015 - Taylor & Francis
Polymyxin B and colistin (polymyxin E) are polypeptide antibiotics that were developed in
the 1940s, but fell into disfavor due to their high toxicity rates. These two antibiotics were …
the 1940s, but fell into disfavor due to their high toxicity rates. These two antibiotics were …
Dose optimization of colistin: A systematic review
Colistin is considered a last treatment option for multi-drug and extensively resistant Gram-
negative infections. We aimed to assess the available data on the dosing strategy of colistin …
negative infections. We aimed to assess the available data on the dosing strategy of colistin …
High-volume hemofiltration in adult burn patients with septic shock and acute kidney injury: a multicenter randomized controlled trial
KK Chung, EC Coates, DJ Smith, RA Karlnoski… - Critical care, 2017 - Springer
Background Sepsis and septic shock occur commonly in severe burns. Acute kidney injury
(AKI) is also common and often results as a consequence of sepsis. Mortality is …
(AKI) is also common and often results as a consequence of sepsis. Mortality is …
Pharmacokinetics, pharmacodynamics, and dose optimization of cefiderocol during continuous renal replacement therapy
Background The need for continuous renal replacement therapy (CRRT) in critically ill
patients with serious infections is associated with clinical failure, emergence of resistance …
patients with serious infections is associated with clinical failure, emergence of resistance …
Evaluation of Pseudomonas aeruginosa pathogenesis and therapeutics in military‐relevant animal infection models
AG Bobrov, D Getnet, B Swierczewski, A Jacobs… - Apmis, 2022 - Wiley Online Library
Modern combat‐related injuries are often associated with acute polytrauma. As a
consequence of severe combat‐related injuries, a dysregulated immune response results in …
consequence of severe combat‐related injuries, a dysregulated immune response results in …
A hydrogel‐based localized release of Colistin for antimicrobial treatment of burn wound infection
There is an urgent unmet medical need for new treatments for wound and burn infections
caused by multidrug‐resistant Gram‐negative “superbugs,” especially the problematic …
caused by multidrug‐resistant Gram‐negative “superbugs,” especially the problematic …
Colistin use in patients with reduced kidney function
Colistin (polymyxin E) is a mainly concentration-dependent bactericidal antimicrobial active
against multidrug-resistant Gram-negative bacteria. After being abandoned over the past 30 …
against multidrug-resistant Gram-negative bacteria. After being abandoned over the past 30 …
Clinical pharmacokinetics, pharmacodynamics and toxicodynamics of polymyxins: implications for therapeutic use
RL Nation, A Forrest - Polymyxin Antibiotics: From Laboratory Bench to …, 2019 - Springer
The availability of sensitive, accurate and specific analytical methods for the measurement of
polymyxins in biological fluids has enabled an understanding of the pharmacokinetics of …
polymyxins in biological fluids has enabled an understanding of the pharmacokinetics of …
Intravenous antibiotic and antifungal agent pharmacokinetic-pharmacodynamic dosing in adults with severe burn injury
Purpose Despite advances in the care of patients with severe burn injury, infection-related
morbidity and mortality remain high and can potentially be reduced with antimicrobial dosing …
morbidity and mortality remain high and can potentially be reduced with antimicrobial dosing …
Synthesis and applications of protein/peptide‐polymer conjugates
P Wilson - Macromolecular Chemistry and Physics, 2017 - Wiley Online Library
Recent advances in synthetic methodologies have brought us closer than ever to the
precision conferred by nature. For example, the control possible in reversible deactivation …
precision conferred by nature. For example, the control possible in reversible deactivation …