Next generation of fluorine-containing pharmaceuticals, compounds currently in phase II–III clinical trials of major pharmaceutical companies: new structural trends …
Y Zhou, J Wang, Z Gu, S Wang, W Zhu… - Chemical …, 2016 - ACS Publications
Fluoroorganic chemistry has become essential in the evolution of many different but
interconnected research fields. These include the development of new materials with a …
interconnected research fields. These include the development of new materials with a …
Viral quasispecies evolution
Evolution of RNA viruses occurs through disequilibria of collections of closely related mutant
spectra or mutant clouds termed viral quasispecies. Here we review the origin of the …
spectra or mutant clouds termed viral quasispecies. Here we review the origin of the …
Boron science
NS Hosmane - New technologies and applications, 2011 - api.taylorfrancis.com
What is boron? The question itself may not seem very significant to many people. Their
introduction to the word “boron” could come as the butt of a joke. Conan O'Brien made jokes …
introduction to the word “boron” could come as the butt of a joke. Conan O'Brien made jokes …
Updated US Public Health Service guidelines for the management of occupational exposures to human immunodeficiency virus and recommendations for …
DT Kuhar, DK Henderson, KA Struble… - Infection Control & …, 2013 - cambridge.org
This report updates US Public Health Service recommendations for the management of
healthcare personnel (HCP) who experience occupational exposure to blood and/or other …
healthcare personnel (HCP) who experience occupational exposure to blood and/or other …
Diagnosing and responding to violations in the positivity assumption
The assumption of positivity or experimental treatment assignment requires that observed
treatment levels vary within confounder strata. This article discusses the positivity …
treatment levels vary within confounder strata. This article discusses the positivity …
Automated analysis of phylogenetic clusters
Background As sequence data sets used for the investigation of pathogen transmission
patterns increase in size, automated tools and standardized methods for cluster analysis …
patterns increase in size, automated tools and standardized methods for cluster analysis …
Antiretroviral therapy and management of HIV infection
PA Volberding, SG Deeks - The Lancet, 2010 - thelancet.com
Antiretroviral therapy of HIV infection has changed a uniformly fatal into a potentially chronic
disease. There are now 17 drugs in common use for HIV treatment. Patients who can access …
disease. There are now 17 drugs in common use for HIV treatment. Patients who can access …
Rilpivirine versus efavirenz with tenofovir and emtricitabine in treatment-naive adults infected with HIV-1 (ECHO): a phase 3 randomised double-blind active-controlled …
JM Molina, P Cahn, B Grinsztejn, A Lazzarin, A Mills… - The Lancet, 2011 - thelancet.com
Background Efavirenz with tenofovir-disoproxil-fumarate and emtricitabine is a preferred
antiretroviral regimen for treatment-naive patients infected with HIV-1. Rilpivirine, a new non …
antiretroviral regimen for treatment-naive patients infected with HIV-1. Rilpivirine, a new non …
Fifteen years of HIV Protease Inhibitors: raising the barrier to resistance
HIV protease plays a crucial role in the viral life cycle and is essential for the generation of
mature infectious virus particles. Detailed knowledge of the structure of HIV protease and its …
mature infectious virus particles. Detailed knowledge of the structure of HIV protease and its …
Rilpivirine versus efavirenz with two background nucleoside or nucleotide reverse transcriptase inhibitors in treatment-naive adults infected with HIV-1 (THRIVE): a …
CJ Cohen, J Andrade-Villanueva, B Clotet, J Fourie… - The Lancet, 2011 - thelancet.com
Background The non-nucleoside reverse transcriptase inhibitor (NNRTI), rilpivirine
(TMC278; Tibotec Pharmaceuticals, County Cork, Ireland), had equivalent sustained efficacy …
(TMC278; Tibotec Pharmaceuticals, County Cork, Ireland), had equivalent sustained efficacy …