Next generation of fluorine-containing pharmaceuticals, compounds currently in phase II–III clinical trials of major pharmaceutical companies: new structural trends …

Y Zhou, J Wang, Z Gu, S Wang, W Zhu… - Chemical …, 2016 - ACS Publications
Fluoroorganic chemistry has become essential in the evolution of many different but
interconnected research fields. These include the development of new materials with a …

Viral quasispecies evolution

E Domingo, J Sheldon, C Perales - Microbiology and Molecular …, 2012 - Am Soc Microbiol
Evolution of RNA viruses occurs through disequilibria of collections of closely related mutant
spectra or mutant clouds termed viral quasispecies. Here we review the origin of the …

Boron science

NS Hosmane - New technologies and applications, 2011 - api.taylorfrancis.com
What is boron? The question itself may not seem very significant to many people. Their
introduction to the word “boron” could come as the butt of a joke. Conan O'Brien made jokes …

Updated US Public Health Service guidelines for the management of occupational exposures to human immunodeficiency virus and recommendations for …

DT Kuhar, DK Henderson, KA Struble… - Infection Control & …, 2013 - cambridge.org
This report updates US Public Health Service recommendations for the management of
healthcare personnel (HCP) who experience occupational exposure to blood and/or other …

Diagnosing and responding to violations in the positivity assumption

ML Petersen, KE Porter, S Gruber… - … methods in medical …, 2012 - journals.sagepub.com
The assumption of positivity or experimental treatment assignment requires that observed
treatment levels vary within confounder strata. This article discusses the positivity …

Automated analysis of phylogenetic clusters

M Ragonnet-Cronin, E Hodcroft, S Hué, E Fearnhill… - BMC …, 2013 - Springer
Background As sequence data sets used for the investigation of pathogen transmission
patterns increase in size, automated tools and standardized methods for cluster analysis …

Antiretroviral therapy and management of HIV infection

PA Volberding, SG Deeks - The Lancet, 2010 - thelancet.com
Antiretroviral therapy of HIV infection has changed a uniformly fatal into a potentially chronic
disease. There are now 17 drugs in common use for HIV treatment. Patients who can access …

Rilpivirine versus efavirenz with tenofovir and emtricitabine in treatment-naive adults infected with HIV-1 (ECHO): a phase 3 randomised double-blind active-controlled …

JM Molina, P Cahn, B Grinsztejn, A Lazzarin, A Mills… - The Lancet, 2011 - thelancet.com
Background Efavirenz with tenofovir-disoproxil-fumarate and emtricitabine is a preferred
antiretroviral regimen for treatment-naive patients infected with HIV-1. Rilpivirine, a new non …

Fifteen years of HIV Protease Inhibitors: raising the barrier to resistance

AMJ Wensing, NM van Maarseveen, M Nijhuis - Antiviral research, 2010 - Elsevier
HIV protease plays a crucial role in the viral life cycle and is essential for the generation of
mature infectious virus particles. Detailed knowledge of the structure of HIV protease and its …

Rilpivirine versus efavirenz with two background nucleoside or nucleotide reverse transcriptase inhibitors in treatment-naive adults infected with HIV-1 (THRIVE): a …

CJ Cohen, J Andrade-Villanueva, B Clotet, J Fourie… - The Lancet, 2011 - thelancet.com
Background The non-nucleoside reverse transcriptase inhibitor (NNRTI), rilpivirine
(TMC278; Tibotec Pharmaceuticals, County Cork, Ireland), had equivalent sustained efficacy …