The identification and characterization of regulatory T (TReg) cells that can control immune
responsiveness to alloantigens have opened up exciting opportunities for new therapies in …

Antigens, provided by the allograft, trigger the activation and proliferation of allospecific T
cells. As a consequence of this response, effector elements are generated that mediate graft …

We present evidence that donor-reactive CD4+ T cells present in mice tolerant to donor
alloantigens are phenotypically and functionally heterogeneous. CD4+ T cells contained …

The ultimate goal of transplantation is drug-free allograft acceptance, which is rarely
encountered in transplant recipients. Using a novel human-to-mouse “trans vivo” delayed …

Abstract Interleukin-10 (IL-10), a cytokine with anti-inflammatory and immunomodulatory
functions, regulates the biology of B and T cells. The present review describes the role of IL …

Evidence is emerging that biomaterials cause inflammation by ligating innate immune
receptors on antigen presenting cells. Although inflammation is usually viewed as …

Previous rat studies with lead (Pb) have shown that exposure throughout the full gestational
period results in persistent immunotoxicity detectable in both juvenile and adult offspring …

Background. We have reported that feeding type V collagen (col (V)) to lung allograft
recipients induces immune tolerance that prevents acute lung allograft rejection. Repeated …

Regulatory T cells (Treg) are important in maintaining immune homeostasis and in
regulating a variety of immune responses, making them attractive targets for modulating …

Immunization with specific proteins or peptides has been used to induce immunologic
tolerance to allografts other than the lung. Recently, we have reported that the immune …