Antimicrobial resistance threatens a resurgence of life-threatening bacterial infections and
the potential demise of many aspects of modern medicine. Despite intensive drug discovery …

Antimicrobial resistance (AMR) is a global health crisis that poses a great threat to modern
medicine. Effective prevention strategies are urgently required to slow the emergence and …

A systems-level understanding of Gram-positive bacteria is important from both an
environmental and health perspective and is most easily obtained when high-quality …

Seminal yeast studies have established the value of comprehensively map** genetic
interactions (GIs) for inferring gene function. Efforts in human cells using focused gene sets …

Behavior depends on coordinated activity across multiple brain regions. Within such
networks, highly connected hub regions are assumed to disproportionately influence …

Efforts to map the Escherichia coli interactome have identified several hundred
macromolecular complexes, but direct binary protein-protein interactions (PPIs) have not …

M. tuberculosis (Mtb) survives a hostile environment within the host that is shaped in part by
oxidative stress. The mechanisms used by Mtb to resist these stresses remain ill-defined …

Bacterial cell envelope protein (CEP) complexes mediate a range of processes, including
membrane assembly, antibiotic resistance and metabolic coordination. However, only …

The fitness effects of a mutation can depend, sometimes dramatically, on genetic
background; this phenomenon is often referred to as “epistasis.” Epistasis can have …

Genetic manipulation of microorganisms has been crucial in understanding their biology, yet
for many microbial species, robust tools for comprehensive genetic analysis were lacking …