Smouldering‐Associated Worsening in Multiple Sclerosis: An International Consensus Statement on Definition, Biology, Clinical Implications, and Future Directions

A Scalfari, A Traboulsee, J Oh, L Airas… - Annals of …, 2024 - Wiley Online Library
Despite therapeutic suppression of relapses, multiple sclerosis (MS) patients often
experience subtle deterioration, which extends beyond the definition of “progression …

An update on the role of magnetic resonance imaging in predicting and monitoring multiple sclerosis progression

P Ananthavarathan, N Sahi… - Expert Review of …, 2024 - Taylor & Francis
Introduction While magnetic resonance imaging (MRI) is established in diagnosing and
monitoring disease activity in multiple sclerosis (MS), its utility in predicting and monitoring …

Can brain network connectivity facilitate the clinical development of disease-modifying anti-Alzheimer drugs?

L Pini, S Lista, A Griffa, G Allali… - Brain …, 2025 - academic.oup.com
The preclinical phase of Alzheimer's disease represents a crucial time window for
therapeutic intervention but requires the identification of clinically relevant biomarkers that …

Microstructure of the cerebellum and its afferent pathways underpins dystonia in myoclonus dystonia

C Tarrano, G Zito, C Galléa, C Delorme… - European Journal of …, 2024 - Wiley Online Library
Abstract Background and Purpose Myoclonus dystonia due to a pathogenic variant in SGCE
(MYC/DYT‐SGCE) is a rare condition involving a motor phenotype associating myoclonus …

Functional and structural lesion network map** in neurological and psychiatric disorders: a systematic review

F Nabizadeh, MH Aarabi - Frontiers in Neurology, 2023 - frontiersin.org
Background The traditional approach to studying the neurobiological mechanisms of brain
disorders and localizing brain function involves identifying brain abnormalities and …

Patterns of cerebral damage in multiple sclerosis and aquaporin-4 antibody-positive neuromyelitis optica spectrum disorders—major differences revealed by non …

P Jakuszyk, A Podlecka-Piętowska… - Brain …, 2024 - academic.oup.com
Multiple sclerosis and aquaporin-4 antibody neuromyelitis optica spectrum disorders are
distinct autoimmune CNS disorders with overlap** clinical features but differing pathology …

Neurite Damage in Patients with Migraine

Y Shibata, S Ishiyama - Neurology International, 2024 - mdpi.com
We examined neurite orientation dispersion and density imaging in patients with migraine.
We found that patients with medication overuse headache exhibited lower orientation …

Magnetic Resonance Imaging Tissue Signatures Associated With White Matter Changes Due to Sporadic Cerebral Small Vessel Disease Indicate That White Matter …

ACC Jochems, S Muñoz Maniega… - Journal of the …, 2024 - Am Heart Assoc
Background White matter hyperintensities (WMHs) might regress and progress
contemporaneously, but we know little about underlying mechanisms. We examined WMH …

Microstructural correlates of olfactory dysfunction in Parkinson's Disease: a systematic review of diffusion MRI studies

H Seyedmirzaei, P Rasoulian, M Parsaei… - Brain Imaging and …, 2024 - Springer
Olfactory dysfunction (OD) is a non-motor symptom of Parkinson's Disease, affecting 75–
95% of the patients. This symptom usually emerges before the clinical diagnosis, and …

[HTML][HTML] Improving the assessment of axonal injury in early multiple sclerosis

AA Toubasi, G Cutter, C Gheen, T Vinarsky, K Yoon… - Academic …, 2024 - Elsevier
Rationale and Objectives Several quantitative magnetic resonance imaging (MRI) methods
are available to measure tissue injury in multiple sclerosis (MS), but their pathological …