The thioredoxin antioxidant system

J Lu, A Holmgren - Free radical biology and medicine, 2014 - Elsevier
The thioredoxin (Trx) system, which is composed of NADPH, thioredoxin reductase (TrxR),
and thioredoxin, is a key antioxidant system in defense against oxidative stress through its …

Transcriptional regulation by Ferric Uptake Regulator (Fur) in pathogenic bacteria

B Troxell, HM Hassan - Frontiers in cellular and infection microbiology, 2013 - frontiersin.org
In the ancient anaerobic environment, ferrous iron (Fe2+) was one of the first metal
cofactors. Oxygenation of the ancient world challenged bacteria to acquire the insoluble …

Antibacterial effects of nanopillar surfaces are mediated by cell impedance, penetration and induction of oxidative stress

J Jenkins, J Mantell, C Neal, A Gholinia… - Nature …, 2020 - nature.com
Some insects, such as dragonflies, have evolved nanoprotrusions on their wings that rupture
bacteria on contact. This has inspired the design of antibacterial implant surfaces with insect …

How microbes defend themselves from incoming hydrogen peroxide

A Sen, JA Imlay - Frontiers in immunology, 2021 - frontiersin.org
Microbes rely upon iron as a cofactor for many enzymes in their central metabolic processes.
The reactive oxygen species (ROS) superoxide and hydrogen peroxide react rapidly with …

Diversity of structures and properties among catalases

P Chelikani, I Fita, PC Loewen - Cellular and Molecular Life Sciences …, 2004 - Springer
More than 300 catalase sequences are now available, divided among monofunctional
catalases (> 225), bifunctional catalase-peroxidases (> 50) and manganese-containing …

Cellular defenses against superoxide and hydrogen peroxide

JA Imlay - Annu. Rev. Biochem., 2008 - annualreviews.org
Life evolved in an anaerobic world; therefore, fundamental enzymatic mechanisms and
biochemical pathways were refined and integrated into metabolism in the absence of any …

Mechanisms of the bactericidal effects of nitrate and nitrite in cured meats

D Majou, S Christieans - Meat Science, 2018 - Elsevier
For cured meat products, nitrite is recognized for its antimicrobial effects against pathogenic
bacteria, even though the specific inhibitory mechanisms are not well known. Nitrite …

Topical application of zinc oxide nanoparticles reduces bacterial skin infection in mice and exhibits antibacterial activity by inducing oxidative stress response and cell …

R Pati, RK Mehta, S Mohanty, A Padhi… - … , Biology and Medicine, 2014 - Elsevier
Here we studied immunological and antibacterial mechanisms of zinc oxide nanoparticles
(ZnO-NPs) against human pathogens. ZnO-NPs showed more activity against …

σB Modulates Virulence Determinant Expression and Stress Resistance: Characterization of a Functional rsbU Strain Derived from Staphylococcus aureus 8325-4

MJ Horsburgh, JL Aish, IJ White, L Shaw… - Journal of …, 2002 - Am Soc Microbiol
The accessory sigma factor σB controls a general stress response that is thought to be
important for Staphylococcus aureus survival and may contribute to virulence. The strain of …

At the crossroads of bacterial metabolism and virulence factor synthesis in Staphylococci

GA Somerville, RA Proctor - Microbiology and Molecular Biology …, 2009 - Am Soc Microbiol
Bacteria live in environments that are subject to rapid changes in the availability of the
nutrients that are necessary to provide energy and biosynthetic intermediates for the …