Apoptotic cell death in disease—Current understanding of the NCCD 2023
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …
Germinal center and extrafollicular B cell responses in vaccination, immunity, and autoimmunity
RA Elsner, MJ Shlomchik - Immunity, 2020 - cell.com
Activated B cells participate in either extrafollicular (EF) or germinal center (GC) responses.
Canonical responses are composed of a short wave of plasmablasts (PBs) arising from EF …
Canonical responses are composed of a short wave of plasmablasts (PBs) arising from EF …
Loss of Bcl-6-expressing T follicular helper cells and germinal centers in COVID-19
Humoral responses in coronavirus disease 2019 (COVID-19) are often of limited durability,
as seen with other human coronavirus epidemics. To address the underlying etiology, we …
as seen with other human coronavirus epidemics. To address the underlying etiology, we …
Infliximab is associated with attenuated immunogenicity to BNT162b2 and ChAdOx1 nCoV-19 SARS-CoV-2 vaccines in patients with IBD
Objective Delayed second dose SARS-CoV-2 vaccination trades maximal effectiveness for a
lower level of immunity across more of the population. We investigated whether patients with …
lower level of immunity across more of the population. We investigated whether patients with …
Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages
T Bohn, S Rapp, N Luther, M Klein, TJ Bruehl… - Nature …, 2018 - nature.com
Many tumors evolve sophisticated strategies to evade the immune system, and these
represent major obstacles for efficient antitumor immune responses. Here we explored a …
represent major obstacles for efficient antitumor immune responses. Here we explored a …
TNF biology, pathogenic mechanisms and emerging therapeutic strategies
GD Kalliolias, LB Ivashkiv - Nature reviews rheumatology, 2016 - nature.com
TNF is a pleiotropic cytokine with important functions in homeostasis and disease
pathogenesis. Recent discoveries have provided insights into TNF biology that introduce …
pathogenesis. Recent discoveries have provided insights into TNF biology that introduce …
[HTML][HTML] TNF-α coordinates hematopoietic stem cell survival and myeloid regeneration
M Yamashita, E Passegué - Cell stem cell, 2019 - cell.com
Inflammation coordinates tissue regeneration via damaged cell removal and stem cell
activation. Hematopoietic stem cells (HSCs) survive inflammatory stress that kills other blood …
activation. Hematopoietic stem cells (HSCs) survive inflammatory stress that kills other blood …
Role of TNF–TNF receptor 2 signal in regulatory T cells and its therapeutic implications
Tumor necrosis factor α (TNFα) is a pleiotropic cytokine which signals through TNF receptor
1 (TNFR1) and TNF receptor 2 (TNFR2). Emerging evidence has demonstrated that TNFR1 …
1 (TNFR1) and TNF receptor 2 (TNFR2). Emerging evidence has demonstrated that TNFR1 …
The molecular mechanisms that underlie the immune biology of anti-drug antibody formation following treatment with monoclonal antibodies
A Vaisman-Mentesh, M Gutierrez-Gonzalez… - Frontiers in …, 2020 - frontiersin.org
Monoclonal antibodies (mAbs) are a crucial asset for human health and modern medicine,
however, the repeated administration of mAbs can be highly immunogenic. Drug …
however, the repeated administration of mAbs can be highly immunogenic. Drug …
Alternatively activated microglia and macrophages in the central nervous system
R Franco, D Fernández-Suárez - Progress in neurobiology, 2015 - Elsevier
Macrophages are important players in the fight against viral, bacterial, fungal and parasitic
infections. From a resting state they may undertake two activation pathways, the classical …
infections. From a resting state they may undertake two activation pathways, the classical …