Corticostriatal circuits through the orbitofrontal cortex (OFC) play key roles in complex
human behaviors such as evaluation, affect regulation and reward-based decision-making …

Compulsivity is associated with alterations in the structure and the function of parallel and
interacting brain circuits involved in emotional processing (involving both the reward and the …

Background Deep brain stimulation (DBS) has been proposed as an alternative to ablative
neurosurgery for severe treatment-resistant Obsessive-Compulsive Disorder (OCD) …

Neuroimaging studies report evidence for two distinct pathophysiological models of
obsessive-compulsive disorder (OCD): disrupted fronto-striatal circuits and impaired large …

Highlights•Involvement of corticostriatal circuits in OCD is receiving strong new experimental
support.•This evidence is concordant with clinical evidence based on OCD patient …

Obsessive–compulsive disorder (OCD) was previously considered refractory to most types
of therapeutic intervention. There is now, however, ample evidence that selective serotonin …

Background Patients with obsessive-compulsive disorder (OCD) experience aversive
emotions in response to obsessions, motivating avoidance and compulsive behaviors …

At the group-level, deep brain stimulation leads to significant therapeutic benefit in a
multitude of neurological and neuropsychiatric disorders. At the single-patient level …

Obsessive-compulsive disorder (OCD) displays widespread disruption across brain regions
revealed by resting-state functional connectivity (rsFC) with inconsistent results between …

The direct estimation of heritability from genome-wide common variant data as implemented
in the program Genome-wide Complex Trait Analysis (GCTA) has provided a means to …