The chemical treatment of cancer started with the realization that DNA damaging agents
such as mustard gas present notable antitumoural properties. Consequently, early drug …

Both embryonic and adult stem cells are endowed with a superior capacity to prevent the
accumulation of genetic lesions, repair them, or avoid their propagation to daughter cells …

Tissue regeneration declines with ageing but little is known about whether this arises from
changes in stem-cell heterogeneity. Here, in homeostatic skeletal muscle, we identify two …

Faithful DNA replication is critical for the maintenance of genomic integrity. Although DNA
replication machinery is highly accurate, the process of DNA replication is constantly …

Maintaining proteostasis is key to resisting stress and promoting healthy aging. Proteostasis
is necessary to preserve stem cell function, but little is known about the mechanisms that …

Background: The adult mammalian cardiomyocytes lose their proliferative capacity, which is
responsible for cardiac dysfunction and heart failure following injury. The molecular …

Human NK cells are innate immune effectors that play a critical roles in the control of viral
infection and malignancy. The importance of their homeostasis and function can be …

During erythroid differentiation, the maintenance of genome integrity is key for the success of
multiple rounds of cell division. However, molecular mechanisms coordinating the …

Soon after birth, the regenerative capacity of the mammalian heart is lost, cardiomyocytes
withdraw from the cell cycle and demonstrate a minimal proliferation rate. Despite improved …

Strict regulation of DNA replication is of fundamental significance for the maintenance of
genome stability. Licensing of origins of DNA replication is a critical event for timely genome …