Stroke is a major contributor to death and disability worldwide. Prior to modern therapy, post-
stroke mortality was approximately 10% in the acute period, with nearly one-half of the …

One in six ischaemic stroke patients has an embolic stroke of undetermined source (ESUS),
defined as a stroke with unclear aetiology despite recommended diagnostic evaluation. The …

Identification of carotid artery atherosclerosis is conventionally based on measurements of
luminal stenosis and surface irregularities using in vivo imaging techniques including …

Background—Recent studies demonstrated that in vivo and ex vivo MRI can characterize
the components of the carotid atherosclerotic plaque, such as fibrous tissue, lipid/necrotic …

Background—Evidence for efficacy of dual antiplatelet therapy in stroke is limited.
Symptomatic carotid stenosis patients are at high risk of early recurrent stroke. In this group …

▪ Abstract The relationship between flow in the arteries, particularly the wall shear stresses,
and the sites where atherosclerosis develops has motivated much of the research on arterial …

ContextRecent studies suggest that factors other than the degree of carotid stenosis are
involved in ischemic stroke pathogenesis, especially modifications of plaque composition …

Background and Purpose—The simplistic view of atherosclerosis as a disorder of
pathological lipid deposition has been redefined by the more complex concept of an …

Background and Purpose—In carotid disease, infarcts can occur in the cortical as well as
internal watershed (WS), or both. Better understanding the pathophysiology of WS infarcts …

BackgroundChlamydia pneumoniae, cytomegalovirus, herpes simplex virus, and recently,
periodontal disease, have been associated with human atherosclerosis. Porphyromonas …