[HTML][HTML] Regulatory insights into nanomedicine and gene vaccine innovation: Safety assessment, challenges, and regulatory perspectives

EB Souto, C Blanco-Llamero, K Krambeck, NS Kiran… - Acta biomaterialia, 2024 - Elsevier
This analysis explores the principal regulatory concerns linked to nanomedicines and gene
vaccines, including the complexities involved and the perspectives on how to navigate them …

Dendritic cells in cancer immunology and immunotherapy

L Hato, A Vizcay, I Eguren, JL Pérez-Gracia… - Cancers, 2024 - mdpi.com
Simple Summary Although immune check point inhibitors have been established as a new
paradigm in cancer treatment, they have shown no clinical benefit in immune excluded or …

DNA vaccines: their formulations, engineering and delivery

M Kozak, J Hu - Vaccines, 2024 - mdpi.com
The concept of DNA vaccination was introduced in the early 1990s. Since then,
advancements in the augmentation of the immunogenicity of DNA vaccines have brought …

The future of cancer immunotherapy: DNA vaccines leading the way

A Pandya, Y Shah, N Kothari, H Postwala, A Shah… - Medical Oncology, 2023 - Springer
Immuno-oncology has revolutionized cancer treatment and has opened up new
opportunities for develo** vaccination methods. DNA-based cancer vaccines have …

Antigen cross-presentation by dendritic cells: A critical axis in cancer immunotherapy

C Moussion, L Delamarre - Seminars in Immunology, 2024 - Elsevier
Dendritic cells (DCs) are professional antigen-presenting cells that play a key role in
sha** adaptive immunity. DCs have a unique ability to sample their environment, capture …

[HTML][HTML] Recent advances in cancer immunotherapy with a focus on FDA-approved vaccines and neoantigen-based vaccines

A Hargrave, AS Mustafa, A Hanif, JH Tunio, SNM Hanif - Vaccines, 2023 - mdpi.com
Cancer immunotherapies refer to the concept of retraining the immune system to target
malignant cells. Multiple immunotherapeutic options exist including immune modulating …

A trinity nano-vaccine system with spatiotemporal immune effect for the adjuvant cancer therapy after radiofrequency ablation

M Li, A Jiang, H Han, M Chen, B Wang, Y Cheng… - ACS …, 2023 - ACS Publications
Cancer vaccine gains great attention with the advances in tumor immunology and
nanotechnology, but its long-term efficacy is restricted by the unsustainable immune activity …

The international clinical trials registry platform (ICTRP): data integrity and the trends in clinical trials, diseases, and drugs

ED Namiot, D Smirnovová, AV Sokolov… - Frontiers in …, 2023 - frontiersin.org
Introduction: Clinical trials are the gold standard for testing new therapies. Databases like
ClinicalTrials. gov provide access to trial information, mainly covering the US and Europe. In …

[HTML][HTML] Advances in melanoma: from genetic insights to therapeutic innovations

F Valdez-Salazar, LA Jiménez-Del Rio… - Biomedicines, 2024 - mdpi.com
Advances in melanoma research have unveiled critical insights into its genetic and
molecular landscape, leading to significant therapeutic innovations. This review explores the …

Tumor-derived antigenic peptides as potential cancer vaccines

S Sotirov, I Dimitrov - International Journal of Molecular Sciences, 2024 - mdpi.com
Peptide antigens derived from tumors have been observed to elicit protective immune
responses, categorized as either tumor-associated antigens (TAAs) or tumor-specific …