The epicardium, the outermost tissue layer that envelops all vertebrate hearts, plays a
crucial role in cardiac development and regeneration and has been implicated in potential …

The epicardium, previously viewed as a passive outer layer around the heart, is now
recognized as an essential component in development, regeneration, and repair. In this …

Defining the mechanisms that govern heart development is essential for identifying the
etiology of congenital heart disease. Here, quantitative proteomics was used to measure …

Trabecular morphogenesis is a key morphologic event during cardiogenesis and contributes
to the formation of a competent ventricular wall. Lack of trabeculation results in embryonic …

Hypoplastic left heart syndrome (HLHS) is a lethal congenital heart disease (CHD) affecting
8–25 per 100,000 neonates globally. Clinical interventions, primarily surgical, have …

The epicardium provides epicardial-derived cells and molecular signals to support cardiac
development and regeneration. Zebrafish and mouse studies have shown that ccm2, a …

The roles of cellular orientation during trabecular and ventricular wall morphogenesis are
unknown, and so are the underlying mechanisms that regulate cellular orientation …

The embryonic epicardium originates from the proepicardium, an extracardiac primordium
constituted by a cluster of mesothelial cells. In early embryos, the embryonic epicardium is …

Hey2 gene mutations in both humans and mice have been associated with multiple cardiac
defects. However, the currently reported localization of Hey2 in the ventricular compact zone …

Congenital heart disease is the most common birth defect worldwide. Defective cardiac
myogenesis is either a major presentation or associated with many types of congenital heart …