Abstract Changes in protein conformation drive most biological processes, but none have
seized the imagination of scientists and the public alike as have the self-replicating …

Amyloid aggregates are associated with a number of mammalian neurodegenerative
diseases. Infectious aggregates of the mammalian prion protein PrP sc are hallmarks of …

Mutations in TARDBP, encoding TAR DNA-binding protein-43 (TDP-43), are associated with
TDP-43 proteinopathies, including amyotrophic lateral sclerosis (ALS) and frontotemporal …

Yeast is one of the oldest domesticated organisms and has both industrial and domestic
applications. In addition, it is very widely used as a eukaryotic model organism in biological …

Human cytomegalovirus (HCMV) has evolved sophisticated immune evasion mechanisms
that target both the innate and adaptive immune responses. However, how HCMV encoded …

Several well-characterized fungal proteins act as prions, proteins capable of multiple
conformations, each with different activities, at least one of which is self-propagating …

Protein synthesis is crucial for the maintenance of long-term-memory-related synaptic
plasticity. The prion-like cytoplasmic polyadenylation element-binding protein 3 (CPEB3) …

Disaggregation of amyloid fibrils is a fundamental biological process required for amyloid
propagation. However, due to the lack of experimental systems, the molecular mechanism of …

A new type of structural extracellular polymers (EPS) was extracted from aerobic granular
sludge dominated by ammonium‐oxidizing bacteria. It was analyzed by Raman and FTIR …

Protein aggregation is a prominent feature of many neurodegenerative diseases, such as
Alzheimer's, Huntington's, and Parkinson's diseases, as well as spongiform …