Non-melanoma skin cancer: what drives tumor development and progression?
P Boukamp - Carcinogenesis, 2005 - academic.oup.com
Non-melanoma skin cancer, ie basal cell carcinoma (BCC) and squamous cell carcinoma
(SCC) are the most frequent tumors and their number is still increasing worldwide (1) …
(SCC) are the most frequent tumors and their number is still increasing worldwide (1) …
c-MYC-induced genomic instability
A Kuzyk, S Mai - Cold Spring Harbor perspectives …, 2014 - perspectivesinmedicine.cshlp.org
MYC dysregulation initiates a dynamic process of genomic instability that is linked to tumor
initiation. Early studies using MYC-carrying retroviruses showed that these viruses were …
initiation. Early studies using MYC-carrying retroviruses showed that these viruses were …
Novel roles for A‐type lamins in telomere biology and the DNA damage response pathway
A‐type lamins are intermediate filament proteins that provide a scaffold for protein
complexes regulating nuclear structure and function. Mutations in the LMNA gene are linked …
complexes regulating nuclear structure and function. Mutations in the LMNA gene are linked …
From micro to nano: recent advances in high-resolution microscopy
Improving the spatial resolution of optical microscopes is important for a vast number of
applications in the life sciences. Optical microscopy allows intact samples and living cells to …
applications in the life sciences. Optical microscopy allows intact samples and living cells to …
Short telomeres may play a role in placental dysfunction in preeclampsia and intrauterine growth restriction
T Biron-Shental, R Sukenik-Halevy, Y Sharon… - American journal of …, 2010 - Elsevier
OBJECTIVE: Telomeres shorten and aggregate with cellular senescence and oxidative
stress. Telomerase and its catalytic component human telomerase reverse-transcriptase …
stress. Telomerase and its catalytic component human telomerase reverse-transcriptase …
c-Myc induces chromosomal rearrangements through telomere and chromosome remodeling in the interphase nucleus
In previous work, we showed that telomeres of normal cells are organized within the 3D
space of the interphase nucleus in a nonoverlap** and cell cycle-dependent manner. This …
space of the interphase nucleus in a nonoverlap** and cell cycle-dependent manner. This …
Locus-specific and activity-independent gene repositioning during early tumorigenesis
The mammalian genome is highly organized within the cell nucleus. The nuclear position of
many genes and genomic regions changes during physiological processes such as …
many genes and genomic regions changes during physiological processes such as …
Characterizing the three‐dimensional organization of telomeres
Background Quantitative analysis can be used in combination with fluorescence
microscopy. Although the human eye is able to obtain good qualitative results, when …
microscopy. Although the human eye is able to obtain good qualitative results, when …
The nuclear lamina promotes telomere aggregation and centromere peripheral localization during senescence of human mesenchymal stem cells
Ex vivo, human mesenchymal stem cells (hMSCs) undergo spontaneous cellular
senescence after a limited number of cell divisions. Intranuclear structures of the nuclear …
senescence after a limited number of cell divisions. Intranuclear structures of the nuclear …
Dynamics of telomeres and promyelocytic leukemia nuclear bodies in a telomerase-negative human cell line
T Jegou, I Chung, G Heuvelman… - Molecular biology of …, 2009 - Am Soc Cell Biol
Telomerase-negative tumor cells maintain their telomeres via an alternative lengthening of
telomeres (ALT) mechanism. This process involves the association of telomeres with …
telomeres (ALT) mechanism. This process involves the association of telomeres with …