The goal of radiation therapy is to achieve maximal therapeutic benefit expressed in terms of
a high probability of local control of disease with minimal side effects. Physically this often …

Scanned particle beams and target motion interfere. This interplay leads to deterioration of
the dose distribution. Experiments and a treatment planning study were performed to …

Historically, the treatment of prostate cancer has required little anatomic information beyond
the location of the prostate gland and adjacent seminal vesicles. Radiation therapy has …

Abstract Treatment delivery with active beam scanning in proton radiation therapy
introduces the problem of interplay effects when pencil beam motion occurs on a similar time …

Clinical outcomes of charged particle therapy are very promising. Currently, several
dedicated centers that use scanning beam technology are either close to clinical use or …

PURPOSE: The objective of this study was to investigate the influence of tumor motion on
dose delivery in stereotactic body radiotherapy (SBRT) for lung cancer, using fixed field …

Purpose Interplay effects in proton radiotherapy can create large distortions in the dose
distribution and severely degrade the plan quality. Standard methods to mitigate these …

The purpose of this study was to develop a method to simulate breathing motion induced
interplay effects for volumetric modulated arc therapy (VMAT), to verify the proposed method …

PURPOSE: To validate the use of stereotactic body radiotherapy (SBRT) using intensity-
modulated radiotherapy (IMRT) beams for medically inoperable Stage I lung cancer …

A method for simulating spot-scanned delivery to a moving tumour was developed which
uses patient-specific image and plan data. The magnitude of interplay effects was …