Turnitin
降AI改写
早检测系统
早降重系统
Turnitin-UK版
万方检测-期刊版
维普编辑部版
Grammarly检测
Paperpass检测
checkpass检测
PaperYY检测
[HTML][HTML] Structure and mechanism of the RNA polymerase II transcription machinery
AC Schier, DJ Taatjes - Genes & development, 2020 - genesdev.cshlp.org
Abstract RNA polymerase II (Pol II) transcribes all protein-coding genes and many
noncoding RNAs in eukaryotic genomes. Although Pol II is a complex, 12-subunit enzyme, it …
noncoding RNAs in eukaryotic genomes. Although Pol II is a complex, 12-subunit enzyme, it …
The role of FACT in managing chromatin: disruption, assembly, or repair?
Abstract FACT (FAcilitates Chromatin Transcription) has long been considered to be a
transcription elongation factor whose ability to destabilize nucleosomes promotes RNAPII …
transcription elongation factor whose ability to destabilize nucleosomes promotes RNAPII …
Structural basis of nucleosome disassembly and reassembly by RNAPII elongation complex with FACT
During gene transcription, RNA polymerase II (RNAPII) traverses nucleosomes in chromatin,
but the mechanism has remained elusive. Using cryo–electron microscopy, we obtained …
but the mechanism has remained elusive. Using cryo–electron microscopy, we obtained …
[HTML][HTML] FACT maintains chromatin architecture and thereby stimulates RNA polymerase II pausing during transcription in vivo
Facilitates chromatin transcription (FACT) is a histone chaperone that supports transcription
through chromatin in vitro, but its functional roles in vivo remain unclear. Here, we analyze …
through chromatin in vitro, but its functional roles in vivo remain unclear. Here, we analyze …
[HTML][HTML] Structure of a backtracked hexasomal intermediate of nucleosome transcription
During gene transcription, RNA polymerase II (RNA Pol II) passes nucleosomes with the
help of various elongation factors. Here, we show that RNA Pol II achieves efficient …
help of various elongation factors. Here, we show that RNA Pol II achieves efficient …
The N-terminus of Spt16 anchors FACT to MCM2–7 for parental histone recycling
Parental histone recycling is vital for maintaining chromatin-based epigenetic information
during replication, yet its underlying mechanisms remain unclear. Here, we uncover an …
during replication, yet its underlying mechanisms remain unclear. Here, we uncover an …
Spt6 directly interacts with Cdc73 and is required for Paf1 complex occupancy at active genes in Saccharomyces cerevisiae
MA Ellison, S Namjilsuren, MK Shirra… - Nucleic Acids …, 2023 - academic.oup.com
Abstract The Paf1 complex (Paf1C) is a conserved transcription elongation factor that
regulates transcription elongation efficiency, facilitates co-transcriptional histone …
regulates transcription elongation efficiency, facilitates co-transcriptional histone …
Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination
SPT6 is a histone chaperone that tightly binds RNA polymerase II (RNAPII) during
transcription elongation. However, its primary role in transcription is uncertain. We used …
transcription elongation. However, its primary role in transcription is uncertain. We used …
Insights into Spt6: a histone chaperone that functions in transcription, DNA replication, and genome stability
CLW Miller, JL Warner, F Winston - Trends in Genetics, 2023 - cell.com
Transcription elongation requires elaborate coordination between the transcriptional
machinery and chromatin regulatory factors to successfully produce RNA while preserving …
machinery and chromatin regulatory factors to successfully produce RNA while preserving …
SETD2: from chromatin modifier to multipronged regulator of the genome and beyond
TM Molenaar, F van Leeuwen - Cellular and Molecular Life Sciences, 2022 - Springer
Histone modifying enzymes play critical roles in many key cellular processes and are
appealing proteins for targeting by small molecules in disease. However, while the functions …
appealing proteins for targeting by small molecules in disease. However, while the functions …