Gene expression involves transcription, translation and the turnover of mRNAs and proteins.
The degree to which protein abundances scale with mRNA levels and the implications in …

Genomes have complex three-dimensional architectures. The recent convergence of
genetic, biochemical, biophysical, and cell biological methods has uncovered several …

The recent increase in genomic data is revealing an unexpected perspective of gene loss as
a pervasive source of genetic variation that can cause adaptive phenotypic diversity. This …

The co-occurrence of diseases can inform the underlying network biology of shared and
multifunctional genes and pathways. In addition, comorbidities help to elucidate the effects …

A now substantial body of science implicates a dynamic interplay between genetic and
environmental variation in the development of individual differences in behavior and health …

As well as undergoing genetic evolution, cancer cells can alter their epigenetic state to
adapt and resist treatment. This non-genetic evolution is emerging as a major component of …

Hundreds of genetic loci increasing risk for neuropsychiatric disorders have recently been
identified. This success, perhaps paradoxically, has posed challenges for therapeutic …

Developmental plasticity refers to the property by which the same genotype produces
distinct phenotypes depending on the environmental conditions under which development …

Recent advances in artificial intelligence are encouraging governments and corporations to
deploy AI in high-stakes settings including driving cars autonomously, managing the power …

Gene networks have yielded numerous neurobiological insights, yet an integrated view
across brain regions is lacking. We leverage RNA sequencing in 864 samples representing …