CCN proteins: opportunities for clinical studies—a personal perspective
H Yeger - Journal of Cell Communication and Signaling, 2023 - Springer
The diverse members of the CCN family now designated as CCN1 (CYR61), CCN2 (CTGF),
CCN3 (NOV), CCN4 (WISP1), CCN5 (WISP2), CCN6 (WISP3) are a conserved matricellular …
CCN3 (NOV), CCN4 (WISP1), CCN5 (WISP2), CCN6 (WISP3) are a conserved matricellular …
Harmonizing hope: navigating the osteoarthritis melody through the CCL2/CCR2 axis for innovative therapeutic avenues
Osteoarthritis (OA) is characterized by a complex interplay of molecular signals orchestrated
by the CCL2/CCR2 axis. The pathogenesis of OA has been revealed to be influenced by a …
by the CCL2/CCR2 axis. The pathogenesis of OA has been revealed to be influenced by a …
Association between weight-adjusted-waist index and the prevalence of rheumatoid arthritis and osteoarthritis: a population-based study
X Wang, L **e, S Yang - BMC Musculoskeletal Disorders, 2023 - Springer
Introduction The weight-adjusted-waist Index (WWI), an innovative metric for assessing
obesity, exhibits superior efficacy in appraising lean muscle and adipose tissue mass …
obesity, exhibits superior efficacy in appraising lean muscle and adipose tissue mass …
CCN proteins in the musculoskeletal system: current understanding and challenges in physiology and pathology
The acronym for the CCN family was recently revised to represent “cellular communication
network”. These six, small, cysteine‐enriched and evolutionarily conserved proteins are …
network”. These six, small, cysteine‐enriched and evolutionarily conserved proteins are …
CTGF as a multifunctional molecule for cartilage and a potential drug for osteoarthritis
Z Yang, W Li, C Song, H Leng - Frontiers in Endocrinology, 2022 - frontiersin.org
CTGF is a multifunctional protein and plays different roles in different cells and under
different conditions. Pamrevlumab, a monoclonal antibody against CTGF, is an FDA …
different conditions. Pamrevlumab, a monoclonal antibody against CTGF, is an FDA …
[HTML][HTML] New potential therapeutic approaches targeting synovial fibroblasts in rheumatoid arthritis
MJ Alcaraz - Biochemical Pharmacology, 2021 - Elsevier
Synovial cells play a key role in joint destruction during chronic inflammation. In particular,
activated synovial fibroblasts (SFs) undergo intrinsic alterations leading to an aggressive …
activated synovial fibroblasts (SFs) undergo intrinsic alterations leading to an aggressive …
The daily intake levels of copper, selenium, and zinc are associated with osteoarthritis but not with rheumatoid arthritis in a cross-sectional study
W Yang, J Lv, Y Wang, Y Xu, J Lin, J Liu, J Chen… - … Trace Element Research, 2023 - Springer
The present study examined potential association between the daily intake and serum levels
of copper (Cu), selenium (Se), and zinc (Zn) and the risk of osteoarthritis (OA) and …
of copper (Cu), selenium (Se), and zinc (Zn) and the risk of osteoarthritis (OA) and …
LncRNA RNA XIST binding to GATA1 contributes to rheumatoid arthritis through its effects on proliferation of synovial fibroblasts and angiogenesis via regulation of …
B Yu, Y Chen, E Chen, F Zuo, Y Yuan, X Zhao… - Molecular …, 2023 - Elsevier
This study explored the role of the long non-coding RNA (lncRNA) XIST (X-inactive specific
transcript) as a driver of RA pathogenesis, with a particular focus on the ability of this lncRNA …
transcript) as a driver of RA pathogenesis, with a particular focus on the ability of this lncRNA …
Taraxasterol inhibits inflammation in osteoarthritis rat model by regulating miRNAs and NF-κB signaling pathway
Z **e, B Wang, C Zheng, Y Qu, J Xu… - Acta Biochimica …, 2022 - abp.ptbioch.edu.pl
Osteoarthritis (OA) has a high incidence rate in the elderly population and is a cause of
chronic degenerative joint disease. Current therapeutic approaches to OA are effective but …
chronic degenerative joint disease. Current therapeutic approaches to OA are effective but …
Comprehensive method for exosome isolation and proteome analysis for detection of CCN factors in/on exosomes
T Eguchi, Y Okusha, Y Lu, K Ono, EA Taha… - CCN Proteins: Methods …, 2022 - Springer
Abstract Cellular Communication Network (CCN) proteins are secretory growth factors often
associated with extracellular matrix (ECM) and extracellular vesicles (EVs) such as …
associated with extracellular matrix (ECM) and extracellular vesicles (EVs) such as …