The human virome: assembly, composition and host interactions

G Liang, FD Bushman - Nature Reviews Microbiology, 2021 - nature.com
The human body hosts vast microbial communities, termed the microbiome. Less well
known is the fact that the human body also hosts vast numbers of different viruses …

Soil viral diversity, ecology and climate change

JK Jansson, R Wu - Nature Reviews Microbiology, 2023 - nature.com
Soil viruses are highly abundant and have important roles in the regulation of host dynamics
and soil ecology. Climate change is resulting in unprecedented changes to soil ecosystems …

Identification of mobile genetic elements with geNomad

AP Camargo, S Roux, F Schulz, M Babinski, Y Xu… - Nature …, 2024 - nature.com
Identifying and characterizing mobile genetic elements in sequencing data is essential for
understanding their diversity, ecology, biotechnological applications and impact on public …

IMG/VR v4: an expanded database of uncultivated virus genomes within a framework of extensive functional, taxonomic, and ecological metadata

AP Camargo, S Nayfach, IMA Chen… - Nucleic acids …, 2023 - academic.oup.com
Viruses are widely recognized as critical members of all microbiomes. Metagenomics
enables large-scale exploration of the global virosphere, progressively revealing the …

VirSorter2: a multi-classifier, expert-guided approach to detect diverse DNA and RNA viruses

J Guo, B Bolduc, AA Zayed, A Varsani… - Microbiome, 2021 - Springer
Background Viruses are a significant player in many biosphere and human ecosystems, but
most signals remain “hidden” in metagenomic/metatranscriptomic sequence datasets due to …

CheckV assesses the quality and completeness of metagenome-assembled viral genomes

S Nayfach, AP Camargo, F Schulz… - Nature …, 2021 - nature.com
Millions of new viral sequences have been identified from metagenomes, but the quality and
completeness of these sequences vary considerably. Here we present CheckV, an …

[HTML][HTML] Expansion of the global RNA virome reveals diverse clades of bacteriophages

U Neri, YI Wolf, S Roux, AP Camargo, B Lee… - Cell, 2022 - cell.com
High-throughput RNA sequencing offers broad opportunities to explore the Earth RNA
virome. Mining 5,150 diverse metatranscriptomes uncovered> 2.5 million RNA virus contigs …

IMG/VR v3: an integrated ecological and evolutionary framework for interrogating genomes of uncultivated viruses

S Roux, D Páez-Espino, IMA Chen… - Nucleic acids …, 2021 - academic.oup.com
Viruses are integral components of all ecosystems and microbiomes on Earth. Through
pervasive infections of their cellular hosts, viruses can reshape microbial community …

Systematic evaluation of horizontal gene transfer between eukaryotes and viruses

NAT Irwin, AA Pittis, TA Richards, PJ Keeling - Nature microbiology, 2022 - nature.com
Gene exchange between viruses and their hosts acts as a key facilitator of horizontal gene
transfer and is hypothesized to be a major driver of evolutionary change. Our understanding …

A deep siamese neural network improves metagenome-assembled genomes in microbiome datasets across different environments

S Pan, C Zhu, XM Zhao, LP Coelho - Nature communications, 2022 - nature.com
Metagenomic binning is the step in building metagenome-assembled genomes (MAGs)
when sequences predicted to originate from the same genome are automatically grouped …