Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …

Genomes of multicellular organisms are characterized by the pervasive expression of
different types of non-coding RNAs (ncRNAs). Long ncRNAs (lncRNAs) belong to a novel …

INTRODUCTION Our understanding of the pathophysiology of psychiatric disorders,
including autism spectrum disorder (ASD), schizophrenia (SCZ), and bipolar disorder (BD) …

SOX2 is a well-characterized pluripotent factor that is essential for stem cell self-renewal,
reprogramming, and homeostasis. The cellular levels of SOX2 are precisely regulated by a …

Genomes of complex organisms encode an abundance and diversity of long noncoding
RNAs (lncRNAs) that are expressed throughout the cell and fulfill a wide variety of regulatory …

With the advent of next generation sequencing methods and progress in transcriptome
analysis, it became obvious that the human genome contains much more than just protein …

Background Accumulating evidence indicates that the long non-coding RNA HOTAIR plays
a critical role in cancer progression and metastasis. However, the overall biological role and …

For 50 years the term 'gene'has been synonymous with regions of the genome encoding
mRNAs that are translated into protein. However, recent genome‐wide studies have shown …

Novel classes of small and long non-coding RNAs (ncRNAs) are being characterized at a
rapid pace, driven by recent paradigm shifts in our understanding of genomic architecture …

The pluripotency-associated transcription factor SOX2 is essential during mammalian
embryogenesis and later in life, but SOX2 expression can also be highly detrimental. Over …