Chalcone derivatives: Role in anticancer therapy

Y Ouyang, J Li, X Chen, X Fu, S Sun, Q Wu - Biomolecules, 2021 - mdpi.com
Chalcones (1, 3-diaryl-2-propen-1-ones) are precursors for flavonoids and isoflavonoids,
which are common simple chemical scaffolds found in many naturally occurring compounds …

[HTML][HTML] Chalcone: A promising bioactive scaffold in medicinal chemistry

G Rajendran, D Bhanu, B Aruchamy, P Ramani… - Pharmaceuticals, 2022 - mdpi.com
Chalcones are a class of privileged scaffolds with high medicinal significance due to the
presence of an α, β-unsaturated ketone functionality. Numerous functional modifications of …

Recent developments in biological activities of chalcones: A mini review

P Singh, A Anand, V Kumar - European journal of medicinal chemistry, 2014 - Elsevier
Chalcones represent key structural motif in the plethora of biologically active molecules
including synthetic and natural products. Synthetic manipulations of chalcones or their …

Plant derived and dietary phenolic antioxidants: Anticancer properties

FMF Roleira, EJ Tavares-da-Silva, CL Varela… - Food Chemistry, 2015 - Elsevier
In this paper, a review of the literature on the phenolic compounds with anticancer activity
published between 2008 and 2012 is presented. In this overview only phenolic antioxidant …

Targeting cancer stem cells and signaling pathways by phytochemicals: Novel approach for breast cancer therapy

PR Dandawate, D Subramaniam, RA Jensen… - Seminars in cancer …, 2016 - Elsevier
Breast cancer is the most common form of cancer diagnosed in women worldwide and the
second leading cause of cancer-related deaths in the USA. Despite the development of …

Synthesis and pharmacological properties of chalcones: a review

SL Gaonkar, UN Vignesh - Research on chemical intermediates, 2017 - Springer
Chalcones and their analogs have been an area of great interest in recent years. Numerous
research papers have been published, and chalcones continue to show promise for new …

Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo

G Sethi, S Chatterjee, P Rajendran, F Li… - Molecular cancer, 2014 - Springer
Background Constitutive activation of signal transducer and activator of transcription 3
(STAT3) has been linked with proliferation, survival, invasion and angiogenesis of a variety …

Garcinol exhibits anti-neoplastic effects by targeting diverse oncogenic factors in tumor cells

V Aggarwal, HS Tuli, J Kaur, D Aggarwal, G Parashar… - Biomedicines, 2020 - mdpi.com
Garcinol, a polyisoprenylated benzophenone, is the medicinal component obtained from
fruits and leaves of Garcinia indica (G. indica) and has traditionally been extensively used …

Cancer Chemotherapy via Natural Bioactive Compounds

K Pathak, MP Pathak, R Saikia, U Gogoi… - Current Drug …, 2022 - benthamdirect.com
Background: Cancer-induced mortality is increasingly prevalent globally, which skyrocketed
the necessity to discover new/novel, safe and effective anticancer drugs. Cancer is …

Therapeutic considerations of bioactive compounds in Alzheimer's disease and Parkinson's disease: Dissecting the molecular pathways

BC Phukan, R Roy, I Gahatraj… - Phytotherapy …, 2023 - Wiley Online Library
Leading neurodegenerative diseases Alzheimer's disease (AD) and Parkinson's disease
(PD) are characterized by the impairment of memory and motor functions, respectively …