Experimental evolution is the study of evolutionary processes occurring in experimental
populations in response to conditions imposed by the experimenter. This research approach …

Artemisinins–the frontline antimalarial drug class–are compromised by emerging resistance,
putting at risk the lives of hundreds of thousands of people each year. Resistance is …

Plasmodium falciparum resistance to artemisinin derivatives in southeast Asia threatens
malaria control and elimination activities worldwide. To monitor the spread of artemisinin …

Artemisinin and its derivatives (ARTs) are the frontline drugs against malaria, but resistance
is jeopardizing their effectiveness. ART resistance is mediated by mutations in the parasite's …

James A. Shapiro proposes an important new paradigm for understanding biological
evolution, the core organizing principle of biology. Shapiro introduces crucial new molecular …

Evolving resistance to artemisinin-based compounds threatens to derail attempts to control
malaria. Resistance has been confirmed in western Cambodia and has recently emerged in …

Abstract Background Artemisinin resistance in Plasmodium falciparum malaria has emerged
in Western Cambodia. This is a major threat to global plans to control and eliminate malaria …

Should ACTs fail, no suitable alternatives exist as first-line treatments of P. falciparum
malaria. Intensified efforts are essential to monitor the spread of resistance, define …

Despite a significant decline in morbidity and mortality over the last two decades, in 2018
there were 228 million reported cases of malaria and 405000 malaria-related deaths …

Background Miltefosine (MF) is the first oral compound used in the chemotherapy against
leishmaniasis. Since the mechanism of action of this drug and the targets of MF in …