Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs.
Our understanding of the genesis of this injury and of potential interventions to prevent, limit …

As the population ages due to demographic trends and gains in life expectancy, the
incidence and prevalence of dementia increases, and the need to understand the etiology …

Increasing evidence suggests that vascular risk factors contribute to neurodegeneration,
cognitive impairment and dementia. While there is considerable overlap between features of …

Aging, hypertension, diabetes, hypoxia/obstructive sleep apnea (OSA), obesity, vitamin
B12/folate deficiency, depression, and traumatic brain injury synergistically promote diverse …

Cerebrovascular disease and vascular risk factors are associated with Alzheimer's disease,
but the evidence for their association with other neurodegenerative disorders is limited …

Brain function critically relies on blood vessels to supply oxygen and nutrients, to establish a
barrier for neurotoxic substances, and to clear waste products. The archetypal vascular …

Many clinical and animal studies demonstrate the importance of long-chain polyunsaturated
fatty acids (LCPUFA) in neural development and neurodegeneration. This review will focus …

Late-onset dementia is a major health concern in the ageing population. Alzheimer's
disease (AD) accounts for the largest proportion (65–70%) of dementia cases in the older …

The possibility that Alzheimer's disease (AD) has a microbial aetiology has been proposed
by several researchers. Here, we provide evidence that tissue from the central nervous …

The blood–brain barrier (BBB) plays critical roles in the maintenance of central nervous
system (CNS) homeostasis. Dysfunction of the BBB occurs in a number of CNS diseases …