Theranostic fluorescent probes

A Sharma, P Verwilst, M Li, D Ma, N Singh… - Chemical …, 2024 - ACS Publications
The ability to gain spatiotemporal information, and in some cases achieve spatiotemporal
control, in the context of drug delivery makes theranostic fluorescent probes an attractive …

Smart molecular designs and applications of activatable organic photosensitizers

E Nestoros, A Sharma, E Kim, JS Kim… - Nature Reviews …, 2024 - nature.com
Photodynamic therapy (PDT)—which combines light, oxygen and photosensitizers (PS) to
generate reactive oxygen species—has emerged as an effective approach for targeted …

Enzyme‐activatable near‐infrared hemicyanines as modular scaffolds for in vivo photodynamic therapy

Z Cheng, S Benson, L Mendive‐Tapia… - Angewandte …, 2024 - Wiley Online Library
Photodynamic therapy is an anti‐cancer treatment that requires illumination of
photosensitizers to induce local cell death. Current near‐infrared organic photosensitizers …

Tumor-microenvironment-activatable organic phototheranostic agents for cancer therapy

S Zeng, Z Guo, Y Hao, YS Kafuti, Z Yang, Q Yao… - Coordination Chemistry …, 2024 - Elsevier
Tumor microenvironment is a rather unusual circumstances formed during the growth of
tumor cells, showing significant differences from normal cells and tissues. Indeed, many …

Valkyrie Probes: A Novel Class of Enzyme‐Activatable Photosensitizers based on Sulfur‐and Seleno‐Rosamines with Pyridinium Unit

V Lioret, K Renault, O Maury… - Chemistry–An Asian …, 2023 - Wiley Online Library
The rational design of activatable photosensitizers (aPSs) uncaged by specific disease
biomarkers is currently booming due to their positive attributes to achieve targeted …

A Supramolecularly Activatable Photosensitizer: Controllable Cyanine J-Aggregation for Efficient Photodynamic Therapy

H Ma, W Xu, X Tang, Y Kang, JF Xu… - CCS Chemistry, 2025 - chinesechemsoc.org
An activatable photosensitizer that could induce phototoxicity only in target sites is highly
demanded to overcome the potential off-target toxicity in photodynamic therapy. It is of great …

Nitric Oxide Activatable Photodynamic Therapy Agents Based on BODIPY–Copper Complexes

H Ilhan, M Şeker, G Gülseren… - ACS Pharmacology & …, 2024 - ACS Publications
In this work, two BODIPY–bipyridine Cu2+ ion complexes for targeted nitric oxide (NO)
activatable photodynamic therapy are reported. The design is based on the relatively high …

Downregulation of gene expression in hypoxic cancer cells by an activatable G-quadruplex stabiliser

B Uyar, NG Ozsamur, FS Celik, I Ozbayram… - Chemical …, 2023 - pubs.rsc.org
In the research, the modulation of gene expression with a novel G-quadruplex stabiliser was
analysed. Activation by the removal of bulky hypoxia-responsive substituent enhances G …

Advancements in Dopamine Research: Exploring Resources, Therapeutic Potential, and Metabolism

N Kawatra, H Singh, S Negi, A Dubey… - Industrial Microbiology and …, 2024 - Springer
Dopamine is a predominant monoamine neurotransmitter that has a critical role in various
physiological processes like cardiovascular regulation, cognitive processes, and renal …

Reprograming cancer cells by a BODIPY G-quadruplex stabiliser

A Baser, B Basar, HB Dogan, G Sener… - Chemical …, 2023 - pubs.rsc.org
A cationic BODIPY-based G-quadruplex-selective stabiliser is developed and shown to
decrease cancer cell migration-invasion up to 90%. The expression of critical genes (HIF1α …