Neural cell adhesion molecules of the immunoglobulin superfamily regulate synapse formation, maintenance, and function

V Sytnyk, I Leshchyns'ka, M Schachner - Trends in neurosciences, 2017 - cell.com
Immunoglobulin superfamily adhesion molecules are among the most abundant proteins in
vertebrate and invertebrate nervous systems. Prominent family members are the neural cell …

Proteomic and transcriptomic profiling of brainstem, cerebellum and olfactory tissues in early-and late-phase COVID-19

J Radke, J Meinhardt, T Aschman, RL Chua… - Nature …, 2024 - nature.com
Neurological symptoms, including cognitive impairment and fatigue, can occur in both the
acute infection phase of coronavirus disease 2019 (COVID-19) and at later stages, yet the …

Synaptic cell adhesion molecules in Alzheimer's disease

I Leshchyns' ka, V Sytnyk - Neural plasticity, 2016 - Wiley Online Library
Alzheimer's disease (AD) is a neurodegenerative brain disorder associated with the loss of
synapses between neurons in the brain. Synaptic cell adhesion molecules are cell surface …

Aβ-dependent reduction of NCAM2-mediated synaptic adhesion contributes to synapse loss in Alzheimer's disease

I Leshchyns' ka, HT Liew, C Shepherd… - Nature …, 2015 - nature.com
Alzheimer's disease (AD) is characterized by synapse loss due to mechanisms that remain
poorly understood. We show that the neural cell adhesion molecule 2 (NCAM2) is enriched …

Copy number variant study of bipolar disorder in Canadian and UK populations implicates synaptic genes

A Noor, AC Lionel, S Cohen‐Woods… - American Journal of …, 2014 - Wiley Online Library
Genome‐wide single nucleotide polymorphism (SNP) data from 936 bipolar disorder (BD)
individuals and 940 psychiatrically healthy comparison individuals of North European …

Copy number variants and infantile spasms: evidence for abnormalities in ventral forebrain development and pathways of synaptic function

AR Paciorkowski, LL Thio, JA Rosenfeld… - European Journal of …, 2011 - nature.com
Infantile spasms (ISS) are an epilepsy disorder frequently associated with severe
developmental outcome and have diverse genetic etiologies. We ascertained 11 subjects …

Cell adhesion molecules involved in neurodevelopmental pathways implicated in 3p-deletion syndrome and autism spectrum disorder

J Gandawijaya, RA Bamford, JPH Burbach… - Frontiers in Cellular …, 2021 - frontiersin.org
Autism spectrum disorder (ASD) is characterized by impaired social interaction, language
delay and repetitive or restrictive behaviors. With increasing prevalence, ASD is currently …

Copy number variants in extended autism spectrum disorder families reveal candidates potentially involved in autism risk

D Salyakina, HN Cukier, JM Lee, S Sacharow… - PloS one, 2011 - journals.plos.org
Copy number variations (CNVs) are a major cause of genetic disruption in the human
genome with far more nucleotides being altered by duplications and deletions than by single …

The role of synaptic cell adhesion molecules and associated scaffolding proteins in social affiliative behaviors

SC Taylor, SL Ferri, M Grewal, Z Smernoff, M Bucan… - Biological …, 2020 - Elsevier
Social affiliative behaviors—engagement in positive (ie, nonaggressive) social approach
and reciprocal social interactions with a conspecific—comprise a construct within the …

Interaction of the cell adhesion molecule CHL1 with vitronectin, integrins, and the plasminogen activator inhibitor-2 promotes CHL1-induced neurite outgrowth and …

J Katic, G Loers, R Kleene, N Karl, C Schmidt… - Journal of …, 2014 - jneurosci.org
The cell adhesion molecule close homolog of L1 (CHL1) plays important functional roles in
the develo** and adult nervous system. In search of the binding partners that mediate the …