Over the past decade, there has been much interest in the regulation of telomerase, the
enzyme responsible for maintaining the integrity of chromosomal ends, and its crucial role in …

BACKGROUND: Atopic dermatitis (AD) is an inflammatory skin disease affecting 10% to
20% of children and 1% to 3% of adults in industrialized countries. Enhanced expression of …

The MYC/MAX/MAD network is of central importance for controlling cell physiology. The
network is compiled of transcriptional regulators that form different heterodimers, which can …

The Myc family of transcription factors regulates a variety of biological processes, including
the cell cycle, growth, proliferation, metabolism, and apoptosis. In Caenorhabditis elegans …

Background We investigated the incidence of eukaryotic translation initiation factor 3 subunit
H (EIF3H) and MYC amplification in non-small cell lung cancer (NSCLC) patients, and …

In human cells the length of telomeres depends on telomerase activity. This activity and the
expression of the catalytic subunit of human telomerase reverse transcriptase (hTERT) is …

The Myc gene has been implicated in the pathogenesis of most types of human cancerous
tumors. Myc/Max activates large numbers of pro-tumor genes; however it also induces anti …

Cancer cells depend on transcription of telomerase reverse transcriptase (TERT). Many
transcription factors affect TERT, though regulation occurs in context of a broader network …

Granulocyte colony-stimulating factor (G-CSF) is a cytokine secreted by stromal cells and
plays a role in the differentiation of bone marrow stem cells and proliferation of neutrophils …

Background The MAD1 protein, a member of the MYC/MAX/MAD network of transcriptional
regulators, controls cell proliferation, differentiation and apoptosis. MAD1 functions as a …