Mortality from severe dengue is low, but the economic and resource burden on health
services remains substantial in endemic settings. Unfortunately, progress towards …

The pathogenesis of dengue virus infection is attributed to complex interplay between virus,
host genes and host immune response. Host factors such as antibody-dependent …

Dengue is widespread throughout the tropics and local spatial variation in dengue virus
transmission is strongly influenced by rainfall, temperature, urbanization and distribution of …

Dengue is caused by the dengue virus (DENVs) infection and clinical manifestations include
dengue fever (DF), dengue hemorrhagic fever (DHF), or dengue shock syndrome (DSS) …

Since its initial isolation in Uganda in 1937 through the present, West Nile virus (WNV) has
become an important cause of human and animal disease worldwide. WNV, an enveloped …

Positive-strand RNA viruses are known to rearrange cellular membranes to facilitate viral
genome replication. The biogenesis and three-dimensional organization of these …

The major medical importance of flaviviruses has fostered studies into their molecular
biology in research laboratories around the world. Although the molecular biology of …

Arthropod-borne viruses (arboviruses) circulate in nature between arthropod vectors and
vertebrate hosts. Arboviruses often cause devastating diseases in vertebrate hosts, but they …

Flaviviruses, such as dengue, Japanese encephalitis, tick-borne encephalitis, West Nile,
yellow fever, and Zika viruses, are critically important human pathogens that sicken a …

The flavivirus nonstructural glycoprotein NS1 is an enigmatic protein whose structure and
mechanistic function have remained somewhat elusive ever since it was first reported in …