The microbiome plays a key role in health and disease, and there has been considerable
interest in therapeutic targeting of the microbiome as well as mining this rich resource in …

Bladder infections affect millions of people yearly, and recurrent symptomatic infections
(cystitis) are very common. The rapid increase in infections caused by multidrug-resistant …

Temperature is a unique input signal that could be used by engineered microbial
therapeutics to sense and respond to host conditions or spatially targeted external triggers …

The metabolism of Archaea, the third domain of life, resembles in its complexity those of
Bacteria and lower Eukarya. However, this metabolic complexity in Archaea is accompanied …

The first bacterial genome was sequenced in 1995, and the first archaeal genome in 1996.
Soon after these breakthroughs, an exponential rate of genome sequencing was …

Synthetic biology continues to progress by relying on more robust tools for transcriptional
control, of which promoters are the most fundamental component. Numerous studies have …

Although it has become routine to consider DNA in terms of its role as a carrier of genetic
information, it is also an important contributor to the control of gene expression. This …

Allostery is essential for controlled catalysis, signal transmission, receptor trafficking, turning
genes on and off, and apoptosis. It governs the organism's response to environmental and …

Charles Darwin believed that all traits of organisms have been honed to near perfection by
natural selection. The empirical basis underlying Darwin's conclusions consisted of …

Diffusion-mediated searching for interaction partners is an ubiquitous process in cell
biology. Transcription factors, for example, search specific DNA sequences, signaling …