The nuclear factor-κB (NF-κB) signaling pathway is one of the most well-studied pathways
related to inflammation, and its involvement in aging has attracted considerable attention. As …

Molecular mechanisms of health and disease are often represented as systems biology
diagrams, and the coverage of such representation constantly increases. These static …

How a cell determines a given phenotype upon damaged DNA is an open problem. Cell fate
decisions happen at cell cycle checkpoints and it is becoming clearer that the p53 pathway …

INTRODUCTION Synthetic biology applies engineering methodologies to biology to build
new functions into living cells. Through the assembly and characterization of engineered …

Motivation Mathematical models of biological processes altered in cancer are built using the
knowledge of complex networks of signaling pathways, detailing the molecular regulations …

This paper addresses two topics in systems biology, the hypothesis that biological systems
are modular and the problem of relating structure and function of biological systems. The …

Network biology is useful for modeling complex biological phenomena; it has attracted
attention with the advent of novel graph-based machine learning methods. However …

Regulatory dependencies in molecular networks are the basis of dynamic behaviors
affecting the phenotypical landscape. With the advance of high throughput technologies, the …

The ability to simulate gene expression and infer gene regulatory networks has vast
potential applications in various fields, including medicine, agriculture, and environmental …

The lncRNA GAS5 acts as a tumor suppressor and is downregulated in gastric cancer (GC).
In contrast, E2F1, an important transcription factor and tumor promoter, directly inhibits miR …