Assessing model mismatch and model selection in a Bayesian uncertainty quantification analysis of a fluid-dynamics model of pulmonary blood circulation

LM Paun, MJ Colebank, MS Olufsen… - Journal of the …, 2020 - royalsocietypublishing.org
This study uses Bayesian inference to quantify the uncertainty of model parameters and
haemodynamic predictions in a one-dimensional pulmonary circulation model based on an …

[HTML][HTML] SECRET: Statistical Emulation for Computational Reverse Engineering and Translation with applications in healthcare

LM Paun, MJ Colebank, A Taylor-LaPole… - Computer Methods in …, 2024 - Elsevier
There have been impressive advances in the physical and mathematical modelling of
complex physiological systems in the last few decades, with the potential to revolutionise …

Uncertainty quantification of regional cardiac tissue properties in arrhythmogenic cardiomyopathy using adaptive multiple importance sampling

N Van Osta, FP Kirkels, T Van Loon, T Koopsen… - Frontiers in …, 2021 - frontiersin.org
Introduction: Computational models of the cardiovascular system are widely used to
simulate cardiac (dys) function. Personalization of such models for patient-specific …

Markov chain Monte Carlo with Gaussian processes for fast parameter estimation and uncertainty quantification in a 1D fluid‐dynamics model of the pulmonary …

LM Paun, D Husmeier - International journal for numerical …, 2021 - Wiley Online Library
The past few decades have witnessed an explosive synergy between physics and the life
sciences. In particular, physical modelling in medicine and physiology is a topical research …

A physiologically realistic virtual patient database for the study of arterial haemodynamics

G Jones, J Parr, P Nithiarasu… - International Journal for …, 2021 - Wiley Online Library
This study creates a physiologically realistic virtual patient database (VPD), representing the
human arterial system, for the primary purpose of studying the effects of arterial disease on …

Fast Posterior Estimation of Cardiac Electrophysiological Model Parameters via Bayesian Active Learning

MS Zaman, J Dhamala, P Bajracharya, JL Sapp… - Frontiers in …, 2021 - frontiersin.org
Probabilistic estimation of cardiac electrophysiological model parameters serves an
important step toward model personalization and uncertain quantification. The expensive …

Emulation-accelerated Hamiltonian Monte Carlo algorithms for parameter estimation and uncertainty quantification in differential equation models

LM Paun, D Husmeier - Statistics and Computing, 2022 - Springer
We propose to accelerate Hamiltonian and Lagrangian Monte Carlo algorithms by coupling
them with Gaussian processes for emulation of the log unnormalised posterior distribution …

[PDF][PDF] Statistical inference for optimisation of drug delivery from stents

LM Paun, AF Schmidt, S McGinty… - Proceedings of the …, 2022 - avestia.com
The current study employs state-of-the-art optimisation methods for estimation of unknown
parameters in a mathematical model of highly non-linear partial differential equations …

Inference in cardiovascular modelling subject to medical interventions

LM Paun, A Borowska, MJ Colebank… - … on Statistics: Theory …, 2021 - research.vu.nl
Abstract Pulmonary hypertension (PH), ie, high blood pressure in the lungs, is a serious
medical condition that can damage the right ventricle of the heart and ultimately lead to heart …

Closed-loop effects in cardiovascular clinical decision support

D Husmeier, LM Paun - 2020 - eprints.gla.ac.uk
We have recently seen impressive methodological developments in quantitative
cardiovascular physiology and pathophysiology, with novel mathematical models for the …