Pathophysiology of chronic graft-versus-host disease and therapeutic targets

R Zeiser, BR Blazar - New England Journal of Medicine, 2017 - Mass Medical Soc
Chronic GVHD, an autoimmune disease that follows allogeneic hematopoietic-cell
transplantation, is characterized by infections and debilitating tissue injury leading to …

[HTML][HTML] The biology of chronic graft-versus-host disease: a task force report from the National Institutes of Health Consensus Development Project on Criteria for …

KR Cooke, L Luznik, S Sarantopoulos, FT Hakim… - Biology of Blood and …, 2017 - Elsevier
Chronic graft-versus-host disease (GVHD) is the leading cause of late, nonrelapse mortality
and disability in allogeneic hematopoietic cell transplantation recipients and a major …

Ruxolitinib for glucocorticoid-refractory chronic graft-versus-host disease

R Zeiser, N Polverelli, R Ram, SK Hashmi… - … England Journal of …, 2021 - Mass Medical Soc
Background Chronic graft-versus-host disease (GVHD), a major complication of allogeneic
stem-cell transplantation, becomes glucocorticoid-refractory or glucocorticoid-dependent in …

Ruxolitinib in corticosteroid-refractory graft-versus-host disease after allogeneic stem cell transplantation: a multicenter survey

R Zeiser, A Burchert, C Lengerke, M Verbeek… - Leukemia, 2015 - nature.com
Despite major improvements in allogeneic hematopoietic cell transplantation over the past
decades, corticosteroid-refractory (SR) acute (a) and chronic (c) graft-versus-host disease …

Chronic graft-versus-host disease: biological insights from preclinical and clinical studies

KPA MacDonald, GR Hill… - Blood, The Journal of the …, 2017 - ashpublications.org
With the increasing use of mismatched, unrelated, and granulocyte colony-stimulating factor–
mobilized peripheral blood stem cell donor grafts and successful treatment of older …

The intestinal microbiota in allogeneic hematopoietic cell transplant and graft-versus-host disease

A Staffas, M Burgos da Silva… - Blood, The Journal of …, 2017 - ashpublications.org
Hematopoietic cell transplantation (HCT) is a critical treatment of patients with high-risk
hematopoietic malignancies, hematological deficiencies, and other immune diseases. In …

Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism

R Flynn, K Paz, J Du, DK Reichenbach… - Blood, The Journal …, 2016 - ashpublications.org
Chronic graft-versus-host disease (cGVHD) remains a major complication following
allogeneic bone marrow transplantation (BMT). The discovery of novel therapeutics is …

New and emerging therapies for acute and chronic graft versus host disease

LQ Hill, A Alousi, P Kebriaei, R Mehta… - Therapeutic …, 2018 - journals.sagepub.com
Graft versus host disease (GVHD) remains a major cause of morbidity and mortality
following allogeneic hematopoietic stem-cell transplantation (HSCT). Despite the use of …

[HTML][HTML] Reprint of: acute graft-versus-host disease: novel biological insights

T Teshima, P Reddy, R Zeiser - Biology of Blood and Marrow …, 2016 - Elsevier
Graft-versus-host disease (GVHD) continues to be a leading cause of morbidity and mortality
after allogeneic hematopoietic stem cell transplantation. Recent insights into intestinal …

Pathogenesis of acute graft‐versus‐host disease: from intestinal microbiota alterations to donor T cell activation

R Zeiser, G Socie, BR Blazar - British journal of haematology, 2016 - Wiley Online Library
Acute graft‐versus‐host disease (aGVHD) is a major life‐threatening complication of
allogeneic haematopoietic cell transplantation (allo‐HCT). Here we discuss the aGVHD …