Adult neurogenesis in the hippocampus: from stem cells to behavior
The dentate gyrus of the mammalian hippocampus continuously generates new neurons
during adulthood. These adult-born neurons become functionally active and are thought to …
during adulthood. These adult-born neurons become functionally active and are thought to …
Restoring Wnt/β-catenin signaling is a promising therapeutic strategy for Alzheimer's disease
Alzheimer's disease (AD) is an aging-related neurological disorder characterized by
synaptic loss and dementia. Wnt/β-catenin signaling is an essential signal transduction …
synaptic loss and dementia. Wnt/β-catenin signaling is an essential signal transduction …
WNT signaling in disease
Developmental signaling pathways control a vast array of biological processes during
embryogenesis and in adult life. The WNT pathway was discovered simultaneously in …
embryogenesis and in adult life. The WNT pathway was discovered simultaneously in …
Wnt signaling in the nervous system and in Alzheimer's disease
Wnts comprise a large family of proteins that have shown to be part of a signaling cascade
that regulates several aspects of development including organogenesis, midbrain …
that regulates several aspects of development including organogenesis, midbrain …
Osteocyte-derived sclerostin impairs cognitive function during ageing and Alzheimer's disease progression
Ageing increases susceptibility to neurodegenerative disorders, such as Alzheimer's
disease (AD). Serum levels of sclerostin, an osteocyte-derived Wnt–β-catenin signalling …
disease (AD). Serum levels of sclerostin, an osteocyte-derived Wnt–β-catenin signalling …
Loss of canonical Wnt signaling is involved in the pathogenesis of Alzheimer's disease
Alzheimer's disease (AD) is the most common form of dementia in the older population,
however, the precise cause of the disease is unknown. The neuropathology is characterized …
however, the precise cause of the disease is unknown. The neuropathology is characterized …
Reversal of synapse degeneration by restoring Wnt signaling in the adult hippocampus
Synapse degeneration occurs early in neurodegenerative diseases and correlates strongly
with cognitive decline in Alzheimer's disease (AD). The molecular mechanisms that trigger …
with cognitive decline in Alzheimer's disease (AD). The molecular mechanisms that trigger …
Wnts in adult brain: from synaptic plasticity to cognitive deficiencies
During development of the central nervous system the Wnt signaling pathway has been
implicated in a wide spectrum of physiological processes, including neuronal connectivity …
implicated in a wide spectrum of physiological processes, including neuronal connectivity …
In vivo activation of Wnt signaling pathway enhances cognitive function of adult mice and reverses cognitive deficits in an Alzheimer's disease model
The role of the Wnt signaling pathway during synaptic development has been well
established. In the adult brain, different components of Wnt signaling are expressed, but little …
established. In the adult brain, different components of Wnt signaling are expressed, but little …
[HTML][HTML] Role of Wnt signaling in synaptic plasticity and memory
Ever since their discoveries, the Wnt pathways have been consistently associated with key
features of cellular development, including metabolism, structure and cell fate. The three …
features of cellular development, including metabolism, structure and cell fate. The three …