Global guideline for the diagnosis and management of cryptococcosis: an initiative of the ECMM and ISHAM in cooperation with the ASM

CC Chang, TS Harrison, TA Bicanic… - The Lancet Infectious …, 2024 - thelancet.com
Cryptococcosis is a major worldwide disseminated invasive fungal infection. Cryptococcosis,
particularly in its most lethal manifestation of cryptococcal meningitis, accounts for …

The antifungal pipeline: a reality check

JR Perfect - Nature reviews Drug discovery, 2017 - nature.com
Invasive fungal infections continue to appear in record numbers as the
immunocompromised population of the world increases, owing partially to the increased …

Fungal infections in HIV/AIDS

AH Limper, A Adenis, T Le… - The Lancet Infectious …, 2017 - thelancet.com
Fungi are major contributors to the opportunistic infections that affect patients with HIV/AIDS.
Systemic infections are mainly with Pneumocystis jirovecii (pneumocystosis), Cryptococcus …

Pulmonary cryptococcosis: a review of pathobiology and clinical aspects

F Setianingrum, R Rautemaa-Richardson… - Medical …, 2019 - academic.oup.com
Pulmonary cryptococcosis is an important opportunistic invasive mycosis in
immunocompromised patients, but it is also increasingly seen in immunocompetent patients …

Fungicide effects on human fungal pathogens: cross-resistance to medical drugs and beyond

RW Bastos, L Rossato, GH Goldman… - PLoS Pathogens, 2021 - journals.plos.org
Fungal infections are underestimated threats that affect over 1 billion people, and Candida
spp., Cryptococcus spp., and Aspergillus spp. are the 3 most fatal fungi. The treatment of …

[HTML][HTML] Pulmonary cryptococcosis

AR Howard-Jones, R Sparks, D Pham, C Halliday… - Journal of Fungi, 2022 - mdpi.com
Pulmonary cryptococcosis describes an invasive lung mycosis caused by Cryptococcus
neoformans or Cryptococcus gattii complex. It is often a high-consequence disease in both …

Combatting the evolution of antifungal resistance in Cryptococcus neoformans

A Bermas, J Geddes‐McAlister - Molecular microbiology, 2020 - Wiley Online Library
Fungal infections are a global concern and the evolution of intrinsic resistance to current
antifungals presents an alarming problem. For Cryptococcus neoformans, a human fungal …

A One Health approach to overcoming fungal disease and antifungal resistance

M Woods, JA McAlister… - WIREs Mechanisms of …, 2023 - Wiley Online Library
The global burden of fungal disease poses a substantial threat to human, animal, and
environmental health, endangering both human and livestock populations and creating …

A systematic review of fluconazole resistance in clinical isolates of Cryptococcus species

F Bongomin, RO Oladele, S Gago, CB Moore… - Mycoses, 2018 - Wiley Online Library
Fluconazole is the most commonly used antifungal agent for both the treatment of
cryptococcal meningitis, and for prophylaxis against the disease. However, its prolonged …

Efficacy of adjunctive sertraline for the treatment of HIV-associated cryptococcal meningitis: an open-label dose-ranging study

J Rhein, BM Morawski, KH Hullsiek… - The Lancet infectious …, 2016 - thelancet.com
Background Cryptococcus is the most common cause of adult meningitis in Africa. We
assessed the safety and microbiological efficacy of adjunctive sertraline, previously shown …